HOTAIR (HOX transcript antisense RNA)

2010-06-01 Affiliation

Identity

HGNC

HOTAIR

LOCATION

12q13.13

LOCUSID

100124700

ALIAS

HOXAS,HOXC-AS4,HOXC11-AS1,NCRNA00072

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 100124700
MIM: 611400
HGNC: 33510
Ensembl: ENSG00000228630

Variants:

dbSNP: 100124700
ClinVar: 100124700
TCGA: ENSG00000228630
COSMIC: HOTAIR

RNA/Proteins

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164713176	Platinum compounds	Chemical	ClinicalAnnotation	associated		PD	26729200
PA444818	Lung Neoplasms	Disease	ClinicalAnnotation	associated		PD	26729200

References

Pubmed ID	Year	Title	Citations
20616235	2010	Long noncoding RNA as modular scaffold of histone modification complexes.	1192
24775712	2014	Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer.	325
24155936	2013	The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21(WAF1/CIP1) expression.	119
25070049	2014	MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway.	109
24118380	2013	HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway.	88
26411689	2015	LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer.	84
25428914	2015	Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner.	83
24953832	2014	Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer.	82
26111795	2015	The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.	65
27041570	2016	NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer.	64

Citation

Dessen P

HOTAIR (HOX transcript antisense RNA)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51537/hotair