HOXA3 (homeobox A3)

2016-10-01  

Identity

HGNC
HOXA3
LOCATION
7p15.2
LOCUSID
3200
ALIAS
HOX1,HOX1E
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3200
MIM: 142954
HGNC: 5104
Ensembl: ENSG00000105997

Variants:

dbSNP: 3200
ClinVar: 3200
TCGA: ENSG00000105997
COSMIC: HOXA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105997ENST00000317201O43365
ENSG00000105997ENST00000317201A0A024RA33
ENSG00000105997ENST00000396352O43365
ENSG00000105997ENST00000396352A0A024RA33
ENSG00000105997ENST00000522456F2Z3A4
ENSG00000105997ENST00000522788E5RIJ8
ENSG00000105997ENST00000612286O43365
ENSG00000105997ENST00000612286A0A024RA33

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
179721632009HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells.11
290737282018HOXA3 promotes tumor growth of human colon cancer through activating EGFR/Ras/Raf/MEK/ERK signaling pathway.11
300668582018Downregulation of HOXA3 in lung adenocarcinoma and its relevant molecular mechanism analysed by RT-qPCR, TCGA and in silico analysis.6
241275332014The absence of mutations in homeobox candidate genes HOXA3, HOXB3, HOXD3 and PITX2 in familial and sporadic thyroid hemiagenesis.1
300461272018The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation.0
313221852019miR‑338‑3p suppresses the malignancy of T‑cell lymphoblastic lymphoma by downregulating HOXA3.0

Citation

Dessen P

HOXA3 (homeobox A3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56189/hoxa3