HOXC4 (homeobox C4)

2014-08-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
HOX3,HOX3E,cp19
FUSION GENES

Other Information

Locus ID:

NCBI: 3221
MIM: 142974
HGNC: 5126
Ensembl: ENSG00000198353

Variants:

dbSNP: 3221
ClinVar: 3221
TCGA: ENSG00000198353
COSMIC: HOXC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198353ENST00000303406P09017
ENSG00000198353ENST00000303406A0A024RB51
ENSG00000198353ENST00000430889P09017
ENSG00000198353ENST00000430889A0A024RB51

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

References

Pubmed IDYearTitleCitations
193634842009HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation.64
208558842010Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation.39
156744122005A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias.23
126728122003Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements.17
152520562004The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination.17
222988212012HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4.10
162159342005Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease.3
192367662009[Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells].1

Citation

Dessen P

HOXC4 (homeobox C4)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54368/hoxc4