HOXC9 (homeobox C9)

2015-05-01 Affiliation

Identity

HGNC

HOXC9

LOCATION

12q13.13

LOCUSID

3225

ALIAS

HOX3,HOX3B

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3225
MIM: 142971
HGNC: 5130
Ensembl: ENSG00000180806

Variants:

dbSNP: 3225
ClinVar: 3225
TCGA: ENSG00000180806
COSMIC: HOXC9

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000180806	ENST00000303450	P31274
ENSG00000180806	ENST00000303450	A0A024RAZ6
ENSG00000180806	ENST00000508190	P31274
ENSG00000180806	ENST00000508190	A0A024RAZ6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
23579273	2013	Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma.	68
21507931	2011	HOXC9 links cell-cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma.	28
19506903	2009	RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China.	23
21493894	2011	The transcription factor HOXC9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8.	18
25444900	2015	MiR-193a-3p promotes the multi-chemoresistance of bladder cancer by targeting the HOXC9 gene.	18
26647900	2016	Fat depot-specific expression of HOXC9 and HOXC10 may contribute to adverse fat distribution and related metabolic traits.	13
17588684	2007	Expression of HOXC9 and E2F2 are up-regulated in CD133(+) cells isolated from human astrocytomas and associate with transformation of human astrocytes.	11
24274069	2013	HOXC9 directly regulates distinct sets of genes to coordinate diverse cellular processes during neuronal differentiation.	11
26582930	2016	Homeobox C9 suppresses Beclin1-mediated autophagy in glioblastoma by directly inhibiting the transcription of death-associated protein kinase 1.	8
30205370	2018	miR-26a/HOXC9 Dysregulation Promotes Metastasis and Stem Cell-Like Phenotype of Gastric Cancer.	4

Citation

Dessen P

HOXC9 (homeobox C9)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55191/hoxc9