HOXD3 (homeobox D3)

2007-02-01 Affiliation

Identity

HGNC

HOXD3

LOCATION

2q31.1

LOCUSID

3232

ALIAS

HOX1D,HOX4,HOX4A,Hox-4.1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3232
MIM: 142980
HGNC: 5137
Ensembl: ENSG00000128652

Variants:

dbSNP: 3232
ClinVar: 3232
TCGA: ENSG00000128652
COSMIC: HOXD3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000128652	ENST00000249440	P31249
ENSG00000128652	ENST00000410016	P31249
ENSG00000128652	ENST00000432796	C9J1M3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Developmental Biology	REACTOME	R-HSA-1266738
Activation of HOX genes during differentiation	REACTOME	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	REACTOME	R-HSA-5617472

References

Pubmed ID	Year	Title	Citations
14610084	2004	The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis.	48
17785556	2007	Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis.	48
21207416	2011	Association of tissue promoter methylation levels of APC, TGFβ2, HOXD3 and RASSF1A with prostate cancer progression.	37
19283074	2009	Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays.	30
14633614	2003	HoxD3 accelerates wound healing in diabetic mice.	24
19453261	2009	High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.	20
20212450	2010	DNA methylation of HOXD3 as a marker of prostate cancer progression.	19
15545924	2004	Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice.	17
27244890	2016	EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway.	17
19938081	2009	Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.	14

Citation

Dessen P

HOXD3 (homeobox D3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45892/hoxd3