HOXD4 (homeobox D4)

2014-11-01  

Identity

HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
HHO.C13,HOX-5.1,HOX4,HOX4B,Hox-4.2

Other Information

Locus ID:

NCBI: 3233
MIM: 142981
HGNC: 5138
Ensembl: ENSG00000170166

Variants:

dbSNP: 3233
ClinVar: 3233
TCGA: ENSG00000170166
COSMIC: HOXD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170166ENST00000306324P09016

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192321362009Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells.65
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
199380812009Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.14
157764342005Mutation analysis of the HOX paralogous 4-13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function.6
206865222010Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families.5
206865222010Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families.5
265450932015Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst.2

Citation

Dessen P

HOXD4 (homeobox D4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64403/hoxd4