HOXD8 (homeobox D8)

2017-04-01  

Identity

HGNC
HOXD8
LOCATION
2q31.1
LOCUSID
3234
ALIAS
HOX4,HOX4E,HOX5.4

Other Information

Locus ID:

NCBI: 3234
MIM: 142985
HGNC: 5139
Ensembl: ENSG00000175879

Variants:

dbSNP: 3234
ClinVar: 3234
TCGA: ENSG00000175879
COSMIC: HOXD8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175879ENST00000313173P13378
ENSG00000175879ENST00000429017A0A0A0MSX5
ENSG00000175879ENST00000450510P13378
ENSG00000175879ENST00000544999A0A0A0MTF4

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
199380812009Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.14
198259362009Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis.9
277489202016microRNA-520a-3p inhibits proliferation and cancer stem cell phenotype by targeting HOXD8 in non-small cell lung cancer.9
284579702017HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer.7
301943402018Potential role of the HOXD8 transcription factor in cisplatin resistance and tumour metastasis in advanced epithelial ovarian cancer.4
306267262019HOXD8/DIAPH2-AS1 epigenetically regulates PAX3 and impairs HTR-8/SVneo cell function under hypoxia.2
309419682019MiR-5692a promotes proliferation and inhibits apoptosis by targeting HOXD8 in hepatocellular carcinoma.0

Citation

Dessen P

HOXD8 (homeobox D8)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56821/hoxd8