HPGDS (hematopoietic prostaglandin D synthase)

2012-09-01 Affiliation

Identity

HGNC

HPGDS

LOCATION

4q22.3

LOCUSID

27306

ALIAS

GSTS,GSTS1,GSTS1-1,PGD2,PGDS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 27306
MIM: 602598
HGNC: 17890
Ensembl: ENSG00000163106

Variants:

dbSNP: 27306
ClinVar: 27306
TCGA: ENSG00000163106
COSMIC: HPGDS

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000163106	ENST00000295256	O60760
ENSG00000163106	ENST00000295256	A0A384P5J0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glutathione metabolism	KEGG	ko00480
Arachidonic acid metabolism	KEGG	ko00590
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Glutathione metabolism	KEGG	hsa00480
Arachidonic acid metabolism	KEGG	hsa00590
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Metabolic pathways	KEGG	hsa01100
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Arachidonic acid metabolism	REACTOME	R-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	REACTOME	R-HSA-2162123
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glutathione conjugation	REACTOME	R-HSA-156590

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19247692	2009	Analyses of associations with asthma in four asthma population samples from Canada and Australia.	39
19276290	2009	Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival.	23
19124506	2009	Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.	22
12627223	2003	Mechanism of metal activation of human hematopoietic prostaglandin D synthase.	18
18946232	2008	Role of prostaglandin D(2) and its receptors in the pathophysiology of asthma.	11
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
12707014	2003	Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin.	10
21683347	2011	Mast cells in human testicular biopsies from patients with mixed atrophy: increased numbers, heterogeneity, and expression of cyclooxygenase 2 and prostaglandin D2 synthase.	10
19181746	2009	Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages.	9

Citation

Dessen P

HPGDS (hematopoietic prostaglandin D synthase)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52862/hpgds