HPGDS (hematopoietic prostaglandin D synthase)

2012-09-01  

Identity

HGNC
LOCATION
4q22.3
LOCUSID
ALIAS
GSTS,GSTS1,GSTS1-1,PGD2,PGDS

Other Information

Locus ID:

NCBI: 27306
MIM: 602598
HGNC: 17890
Ensembl: ENSG00000163106

Variants:

dbSNP: 27306
ClinVar: 27306
TCGA: ENSG00000163106
COSMIC: HPGDS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163106ENST00000295256O60760
ENSG00000163106ENST00000295256A0A384P5J0

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Arachidonic acid metabolismKEGGko00590
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Arachidonic acid metabolismKEGGhsa00590
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Metabolic pathwaysKEGGhsa01100
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)REACTOMER-HSA-2162123
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383391252024Hematopoietic Prostaglandin D Synthase Is Increased in Mast Cells and Pericytes in Autopsy Myocardial Specimens from Patients with Duchenne Muscular Dystrophy.0
383391252024Hematopoietic Prostaglandin D Synthase Is Increased in Mast Cells and Pericytes in Autopsy Myocardial Specimens from Patients with Duchenne Muscular Dystrophy.0
271452332016Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal association with childhood asthma.12
274852702016Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase.2
271452332016Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal association with childhood asthma.12
274852702016Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase.2
249964172014Inhibition of hematopoietic prostaglandin D2 synthase (H-PGDS) by an alkaloid extract from Combretum molle.4
249964172014Inhibition of hematopoietic prostaglandin D2 synthase (H-PGDS) by an alkaloid extract from Combretum molle.4
218211442012Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer.6
220490222012Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin-proteasome system in response to intracellular calcium level.9
218211442012Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer.6
220490222012Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin-proteasome system in response to intracellular calcium level.9
216833472011Mast cells in human testicular biopsies from patients with mixed atrophy: increased numbers, heterogeneity, and expression of cyclooxygenase 2 and prostaglandin D2 synthase.13
216833472011Mast cells in human testicular biopsies from patients with mixed atrophy: increased numbers, heterogeneity, and expression of cyclooxygenase 2 and prostaglandin D2 synthase.13
200748082010UV resonance Raman studies on the activation mechanism of human hematopoietic prostaglandin D(2) synthase by a divalent cation, Mg(2+).3

Citation

Dessen P

HPGDS (hematopoietic prostaglandin D synthase)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52862/hpgds