HPR (haptoglobin-related protein)

2012-11-01  

Identity

HGNC
LOCATION
16q22.2
LOCUSID
ALIAS
A-259H10.2,HP
FUSION GENES

Other Information

Locus ID:

NCBI: 3250
MIM: 140210
HGNC: 5156
Ensembl: ENSG00000261701

Variants:

dbSNP: 3250
ClinVar: 3250
TCGA: ENSG00000261701
COSMIC: HPR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000261701ENST00000356967A0A0A0MRD9
ENSG00000261701ENST00000540303P00739
ENSG00000261701ENST00000561690J3KTC3
ENSG00000261701ENST00000649683A0A3B3ISM1

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging of heme from plasmaREACTOMER-HSA-2168880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
208055082010Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor.42
167781362006Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein.32
178450742007Hemoglobin is a co-factor of human trypanosome lytic factor.26
173604872007Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum.24
193248782009Membrane permeabilization by trypanosome lytic factor, a cytolytic human high density lipoprotein.20
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
224334452012Complexity of a complex trait locus: HP, HPR, haemoglobin and cholesterol.5
250372182014A retained secretory signal peptide mediates high density lipoprotein (HDL) assembly and function of haptoglobin-related protein.4

Citation

Dessen P

HPR (haptoglobin-related protein)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53009/hpr