Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3251
MIM: 308000
HGNC: 5157
Ensembl: ENSG00000165704
Variants:
dbSNP: 3251
ClinVar: 3251
TCGA: ENSG00000165704
COSMIC: HPRT1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000165704 | ENST00000298556 | P00492 |
| ENSG00000165704 | ENST00000298556 | A0A140VJL3 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164748728 | mycophenolic acid | Chemical | LabelAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37737247 | 2023 | Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas. | 2 |
| 37737247 | 2023 | Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas. | 2 |
| 35114018 | 2022 | Hypoxanthine-guanine phosphoribosyltransferase is activated via positive cooperativity between guanine and IMP. | 2 |
| 36178927 | 2022 | Expression variation of OGG1 and HPRT gene and DNA damage in arsenic exposed industrial workers. | 2 |
| 35114018 | 2022 | Hypoxanthine-guanine phosphoribosyltransferase is activated via positive cooperativity between guanine and IMP. | 2 |
| 36178927 | 2022 | Expression variation of OGG1 and HPRT gene and DNA damage in arsenic exposed industrial workers. | 2 |
| 33340493 | 2021 | HPRT promotes proliferation and metastasis in head and neck squamous cell carcinoma through direct interaction with STAT3. | 9 |
| 34231338 | 2021 | Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma. | 15 |
| 33340493 | 2021 | HPRT promotes proliferation and metastasis in head and neck squamous cell carcinoma through direct interaction with STAT3. | 9 |
| 34231338 | 2021 | Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma. | 15 |
| 32826875 | 2020 | In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations. | 2 |
| 32826875 | 2020 | In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations. | 2 |
| 30831305 | 2019 | Understanding the structure-function relationship of HPRT1 missense mutations in association with Lesch-Nyhan disease and HPRT1-related gout by in silico mutational analysis. | 9 |
| 31240211 | 2019 | PPIA, HPRT1, and YWHAZ Genes Are Suitable for Normalization of mRNA Expression in Long-Term Expanded Human Mesenchymal Stem Cells. | 12 |
| 30831305 | 2019 | Understanding the structure-function relationship of HPRT1 missense mutations in association with Lesch-Nyhan disease and HPRT1-related gout by in silico mutational analysis. | 9 |
Citation
Dessen P
HPRT1 (hypoxanthine phosphoribosyltransferase 1)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43310/hprt1
