HPSE (heparanase)

2003-02-01  

Identity

HGNC
LOCATION
4q21.23
LOCUSID
ALIAS
HPA,HPA1,HPR1,HPSE1,HSE1

Other Information

Locus ID:

NCBI: 10855
MIM: 604724
HGNC: 5164
Ensembl: ENSG00000173083

Variants:

dbSNP: 10855
ClinVar: 10855
TCGA: ENSG00000173083
COSMIC: HPSE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173083ENST00000311412Q9Y251
ENSG00000173083ENST00000405413Q9Y251
ENSG00000173083ENST00000507150D6RHG4
ENSG00000173083ENST00000508891D6RAQ1
ENSG00000173083ENST00000509906Q9Y251
ENSG00000173083ENST00000512196Q9Y251
ENSG00000173083ENST00000513463Q9Y251

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Glycosaminoglycan degradationKEGGko00531
Glycosaminoglycan degradationKEGGhsa00531
Metabolic pathwaysKEGGhsa01100
Heparan sulfate degradationKEGGhsa_M00078
Heparan sulfate degradationKEGGM00078
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
HS-GAG degradationREACTOMER-HSA-2024096
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
287942022017CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.143
258491342015Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes.123
200978822010Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis.99
234307392013Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes.99
188123152008Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.81
212577202011SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis.80
173394232007Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma.72
257326772015Heparanase activates the syndecan-syntenin-ALIX exosome pathway.71
147698192004Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior.69
214903962011Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.65

Citation

Dessen P

HPSE (heparanase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40858/hpse