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HRG (histidine-rich glycoprotein)

Identity

Other namesHPRG
HRGP
THPH11
HGNC (Hugo) HRG
LocusID (NCBI) 3273
Location 3q27.3
Location_base_pair Starts at 186383747 and ends at 186396023 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HRG   5181
Cards
Entrez_Gene (NCBI)HRG  3273  histidine-rich glycoprotein
GeneCards (Weizmann)HRG
Ensembl (Hinxton)ENSG00000113905 [Gene_View]  chr3:186383747-186396023 [Contig_View]  HRG [Vega]
ICGC DataPortalENSG00000113905
AceView (NCBI)HRG
Genatlas (Paris)HRG
WikiGenes3273
SOURCE (Princeton)NM_000412
Genomic and cartography
GoldenPath (UCSC)HRG  -  3q27.3   chr3:186383747-186396023 +  3q27.3   [Description]    (hg19-Feb_2009)
EnsemblHRG - 3q27.3 [CytoView]
Mapping of homologs : NCBIHRG [Mapview]
OMIM142640   613116   
Gene and transcription
Genbank (Entrez)AI800281 AK313381 BC069574 BC150591 CR749302
RefSeq transcript (Entrez)NM_000412
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_021485 NT_005612 NW_001838884 NW_004929311
Consensus coding sequences : CCDS (NCBI)HRG
Cluster EST : UnigeneHs.1498 [ NCBI ]
CGAP (NCI)Hs.1498
Alternative Splicing : Fast-db (Paris)GSHG0021400
Alternative Splicing GalleryENSG00000113905
Gene ExpressionHRG [ NCBI-GEO ]     HRG [ SEEK ]   HRG [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04196 (Uniprot)
NextProtP04196  [Medical]
With graphics : InterProP04196
Splice isoforms : SwissVarP04196 (Swissvar)
Domains : Interpro (EBI)Prot_inh_cystat   
Related proteins : CluSTrP04196
Domain families : Pfam (Sanger)Cystatin (PF00031)   
Domain families : Pfam (NCBI)pfam00031   
Domain families : Smart (EMBL)CY (SM00043)  
DMDM Disease mutations3273
Blocks (Seattle)P04196
Human Protein AtlasENSG00000113905
Peptide AtlasP04196
HPRD00812
IPIIPI00022371   
Protein Interaction databases
DIP (DOE-UCLA)P04196
IntAct (EBI)P04196
FunCoupENSG00000113905
BioGRIDHRG
InParanoidP04196
Interologous Interaction database P04196
IntegromeDBHRG
STRING (EMBL)HRG
Ontologies - Pathways
Ontology : AmiGOangiogenesis  platelet degranulation  positive regulation of immune response to tumor cell  serine-type endopeptidase inhibitor activity  cysteine-type endopeptidase inhibitor activity  receptor binding  protein binding  extracellular region  extracellular region  extracellular region  plasma membrane  chemotaxis  negative regulation of cell adhesion  blood coagulation  heparin binding  zinc ion binding  negative regulation of cell proliferation  regulation of gene expression  regulation of platelet activation  negative regulation of lamellipodium assembly  negative regulation of endopeptidase activity  negative regulation of angiogenesis  immunoglobulin binding  heme binding  platelet activation  platelet activation  regulation of blood coagulation  negative regulation of cell growth  platelet alpha granule lumen  regulation of actin cytoskeleton organization  negative regulation of cell adhesion mediated by integrin  fibrinolysis  positive regulation of apoptotic process  regulation of protein complex assembly  heparan sulfate proteoglycan binding  negative regulation of blood vessel endothelial cell migration  metal ion binding  regulation of peptidyl-tyrosine phosphorylation  defense response to fungus  positive regulation of focal adhesion assembly  negative regulation of fibrinolysis  extracellular vesicular exosome  blood microparticle  negative regulation of vascular endothelial growth factor signaling pathway  positive regulation of blood vessel remodeling  negative regulation of endothelial cell chemotaxis  
Ontology : EGO-EBIangiogenesis  platelet degranulation  positive regulation of immune response to tumor cell  serine-type endopeptidase inhibitor activity  cysteine-type endopeptidase inhibitor activity  receptor binding  protein binding  extracellular region  extracellular region  extracellular region  plasma membrane  chemotaxis  negative regulation of cell adhesion  blood coagulation  heparin binding  zinc ion binding  negative regulation of cell proliferation  regulation of gene expression  regulation of platelet activation  negative regulation of lamellipodium assembly  negative regulation of endopeptidase activity  negative regulation of angiogenesis  immunoglobulin binding  heme binding  platelet activation  platelet activation  regulation of blood coagulation  negative regulation of cell growth  platelet alpha granule lumen  regulation of actin cytoskeleton organization  negative regulation of cell adhesion mediated by integrin  fibrinolysis  positive regulation of apoptotic process  regulation of protein complex assembly  heparan sulfate proteoglycan binding  negative regulation of blood vessel endothelial cell migration  metal ion binding  regulation of peptidyl-tyrosine phosphorylation  defense response to fungus  positive regulation of focal adhesion assembly  negative regulation of fibrinolysis  extracellular vesicular exosome  blood microparticle  negative regulation of vascular endothelial growth factor signaling pathway  positive regulation of blood vessel remodeling  negative regulation of endothelial cell chemotaxis  
Protein Interaction DatabaseHRG
Wikipedia pathwaysHRG
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)HRG
SNP (GeneSNP Utah)HRG
SNP : HGBaseHRG
Genetic variants : HAPMAPHRG
1000_GenomesHRG 
ICGC programENSG00000113905 
CONAN: Copy Number AnalysisHRG 
Somatic Mutations in Cancer : COSMICHRG 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDHRG
OMIM142640    613116   
MedgenHRG
GENETestsHRG
Disease Genetic AssociationHRG
Huge Navigator HRG [HugePedia]  HRG [HugeCancerGEM]
Genomic VariantsHRG  HRG [DGVbeta]
Exome VariantHRG
dbVarHRG
ClinVarHRG
snp3D : Map Gene to Disease3273
General knowledge
Homologs : HomoloGeneHRG
Homology/Alignments : Family Browser (UCSC)HRG
Phylogenetic Trees/Animal Genes : TreeFamHRG
Chemical/Protein Interactions : CTD3273
Chemical/Pharm GKB GenePA29455
Clinical trialHRG
Cancer Resource (Charite)ENSG00000113905
Other databases
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
CoreMineHRG
iHOPHRG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:51:34 CEST 2014

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