Identity
HGNC
LOCATION
3p25.3
LOCUSID
ALIAS
H1-R,H1R,HH1R,hisH1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3269
MIM: 600167
HGNC: 5182
Ensembl: ENSG00000196639
Variants:
dbSNP: 3269
ClinVar: 3269
TCGA: ENSG00000196639
COSMIC: HRH1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000196639 | ENST00000397056 | P35367 |
| ENSG00000196639 | ENST00000413416 | C9J2E6 |
| ENSG00000196639 | ENST00000431010 | P35367 |
| ENSG00000196639 | ENST00000438284 | P35367 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406954 | Weight gain | Disease | MultilinkAnnotation | associated | 24279860 | ||
| PA164776964 | desloratadine | Chemical | ClinicalAnnotation | associated | PD | 31406237 | |
| PA166129521 | sedation | Disease | ClinicalAnnotation | associated | PD | 31406237 | |
| PA445999 | Urticaria | Disease | ClinicalAnnotation | associated | PD | 31406237 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37977823 | 2024 | Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H(1) Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine. | 0 |
| 38542369 | 2024 | Histamine H(1) Receptor-Mediated JNK Phosphorylation Is Regulated by G(q) Protein-Dependent but Arrestin-Independent Pathways. | 0 |
| 37977823 | 2024 | Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H(1) Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine. | 0 |
| 38542369 | 2024 | Histamine H(1) Receptor-Mediated JNK Phosphorylation Is Regulated by G(q) Protein-Dependent but Arrestin-Independent Pathways. | 0 |
| 36732336 | 2023 | Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration. | 4 |
| 37201878 | 2023 | Differential regulation of histamine H(1) receptor-mediated ERK phosphorylation by G(q) proteins and arrestins. | 1 |
| 37300703 | 2023 | Histamine H(1)- and H(4)-receptor expression in human colon-derived cell lines. | 0 |
| 36732336 | 2023 | Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration. | 4 |
| 37201878 | 2023 | Differential regulation of histamine H(1) receptor-mediated ERK phosphorylation by G(q) proteins and arrestins. | 1 |
| 37300703 | 2023 | Histamine H(1)- and H(4)-receptor expression in human colon-derived cell lines. | 0 |
| 34595742 | 2022 | Molecular Signaling and Transcriptional Regulation of Histamine H(1) Receptor Gene. | 4 |
| 35031480 | 2022 | Epigallocatechin gallate stimulated histamine production and downregulated histamine H1 receptor in oral cancer cell lines expressing histidine decarboxylase. | 1 |
| 34595742 | 2022 | Molecular Signaling and Transcriptional Regulation of Histamine H(1) Receptor Gene. | 4 |
| 35031480 | 2022 | Epigallocatechin gallate stimulated histamine production and downregulated histamine H1 receptor in oral cancer cell lines expressing histidine decarboxylase. | 1 |
| 33918180 | 2021 | Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410(6.30×30)K Variant in the Histamine H(1) Receptor. | 4 |
Citation
Dessen P
HRH1 (histamine receptor H1)
Atlas Genet Cytogenet Oncol Haematol. 2008-09-01
Online version: http://atlasgeneticsoncology.org/gene/50324/hrh1
