Identity
HGNC
LOCATION
18q11.2
LOCUSID
ALIAS
AXOR35,BG26,GPCR105,GPRv53,H4,H4R,HH4R
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 59340
MIM: 606792
HGNC: 17383
Ensembl: ENSG00000134489
Variants:
dbSNP: 59340
ClinVar: 59340
TCGA: ENSG00000134489
COSMIC: HRH4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000134489 | ENST00000256906 | Q9H3N8 |
| ENSG00000134489 | ENST00000426880 | Q9H3N8 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 23422377 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | 23422377 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37300703 | 2023 | Histamine H(1)- and H(4)-receptor expression in human colon-derived cell lines. | 0 |
| 37300703 | 2023 | Histamine H(1)- and H(4)-receptor expression in human colon-derived cell lines. | 0 |
| 34432256 | 2022 | Histamine-4 Receptor: Emerging Target for the Treatment of Neurological Diseases. | 2 |
| 35163302 | 2022 | Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma. | 5 |
| 35227109 | 2022 | Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study. | 2 |
| 36091066 | 2022 | Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma. | 4 |
| 34432256 | 2022 | Histamine-4 Receptor: Emerging Target for the Treatment of Neurological Diseases. | 2 |
| 35163302 | 2022 | Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma. | 5 |
| 35227109 | 2022 | Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study. | 2 |
| 36091066 | 2022 | Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma. | 4 |
| 34439793 | 2021 | Identification of TSPAN4 as Novel Histamine H(4) Receptor Interactor. | 6 |
| 34439793 | 2021 | Identification of TSPAN4 as Novel Histamine H(4) Receptor Interactor. | 6 |
| 31748740 | 2020 | Study of the antitumour effects and the modulation of immune response by histamine in breast cancer. | 12 |
| 31748740 | 2020 | Study of the antitumour effects and the modulation of immune response by histamine in breast cancer. | 12 |
| 30767014 | 2019 | Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase. | 9 |
Citation
Dessen P
HRH4 (histamine receptor H4)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45609/hrh4
