HS2ST1 (heparan sulfate 2-O-sulfotransferase 1)

2014-11-01  

Identity

HGNC
LOCATION
1p22.3
LOCUSID
ALIAS
NFSRA,dJ604K5.2
FUSION GENES

Other Information

Locus ID:

NCBI: 9653
MIM: 604844
HGNC: 5193
Ensembl: ENSG00000153936

Variants:

dbSNP: 9653
ClinVar: 9653
TCGA: ENSG00000153936
COSMIC: HS2ST1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153936ENST00000370550Q7LGA3
ENSG00000153936ENST00000370551Q7LGA3
ENSG00000153936ENST00000591456K7EP71

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Glycosaminoglycan biosynthesis - heparan sulfate / heparinKEGGko00534
Glycosaminoglycan biosynthesis - heparan sulfate / heparinKEGGhsa00534
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
HS-GAG biosynthesisREACTOMER-HSA-2022928

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
172277542007Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.13
210480312011Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.5
255947472015C5-epimerase and 2-O-sulfotransferase associate in vitro to generate contiguous epimerized and 2-O-sulfated heparan sulfate domains.4

Citation

Dessen P

HS2ST1 (heparan sulfate 2-O-sulfotransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64427/hs2st1