HS6ST1 (heparan sulfate 6-O-sulfotransferase 1)

2014-06-01  

Identity

HGNC
LOCATION
2q14.3
LOCUSID
ALIAS
HH15,HS6ST
FUSION GENES

Other Information

Locus ID:

NCBI: 9394
MIM: 604846
HGNC: 5201
Ensembl: ENSG00000136720

Variants:

dbSNP: 9394
ClinVar: 9394
TCGA: ENSG00000136720
COSMIC: HS6ST1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136720ENST00000259241O60243

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Glycosaminoglycan biosynthesis - heparan sulfate / heparinKEGGko00534
Glycosaminoglycan biosynthesis - heparan sulfate / heparinKEGGhsa00534
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
HS-GAG biosynthesisREACTOMER-HSA-2022928

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
217008822011Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism.51
245634832014Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling.19
245013772014Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development.17
124923992003Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.15
299313542018HS6ST1 Insufficiency Causes Self-Limited Delayed Puberty in Contrast With Other GnRH Deficiency Genes.6
291042772017Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma Due to EXT1/2 and HS6ST1/2 Down-Regulation.3

Citation

Dessen P

HS6ST1 (heparan sulfate 6-O-sulfotransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/54037/hs6st1