HSBP1 (heat shock factor binding protein 1)

2015-05-01 Affiliation

Identity

HGNC

HSBP1

LOCATION

16q23.3

LOCUSID

3281

ALIAS

NPC-A-13

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3281
MIM: 604553
HGNC: 5203
Ensembl: ENSG00000230989

Variants:

dbSNP: 3281
ClinVar: 3281
TCGA: ENSG00000230989
COSMIC: HSBP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000230989	ENST00000433866	O75506
ENSG00000230989	ENST00000567382	H3BR28
ENSG00000230989	ENST00000570259	O75506

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
HSF1 activation	REACTOME	R-HSA-3371511
HSF1-dependent transactivation	REACTOME	R-HSA-3371571
Attenuation phase	REACTOME	R-HSA-3371568

References

Pubmed ID	Year	Title	Citations
11679589	2002	Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain.	15
28332148	2017	pH-dependent structural modulation is conserved in the human small heat shock protein HSBP1.	15
29323280	2018	Nucleotide exchange factors Fes1 and HspBP1 mimic substrate to release misfolded proteins from Hsp70.	12
18767159	2009	Crystal structure of the hexamer of human heat shock factor binding protein 1.	10
21247889	2011	The heat shock-binding protein (HspBP1) protects cells against the cytotoxic action of the Tag7-Hsp70 complex.	5
29844016	2018	The trimeric coiled-coil HSBP1 protein promotes WASH complex assembly at centrosomes.	5
28828227	2017	A novel p.T139M mutation in HSPB1 highlighting the phenotypic spectrum in a family.	3
24816843	2014	Overexpression of HSBP1 is associated with resistance to radiotherapy in oral squamous epithelial carcinoma.	1
31015126	2019	The single nucleotide variant rs2868371 associates with the risk of mortality in non-small cell lung cancer patients: A multicenter prospective validation.	0

Citation

Dessen P

HSBP1 (heat shock factor binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55192/hsbp1