Identity
HGNC
LOCATION
22q12.1
LOCUSID
ALIAS
DNAJC20,HSC20,JAC1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 150274
MIM: 608142
HGNC: 28913
Ensembl: ENSG00000100209
Variants:
dbSNP: 150274
ClinVar: 150274
TCGA: ENSG00000100209
COSMIC: HSCB
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism of proteins | REACTOME | R-HSA-392499 |
| Mitochondrial protein import | REACTOME | R-HSA-1268020 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37871810 | 2024 | Structural characterization of the human DjC20/HscB cochaperone in solution. | 0 |
| 38757931 | 2024 | PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis. | 0 |
| 37871810 | 2024 | Structural characterization of the human DjC20/HscB cochaperone in solution. | 0 |
| 38757931 | 2024 | PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis. | 0 |
| 29211945 | 2018 | Regulation of human Nfu activity in Fe-S cluster delivery-characterization of the interaction between Nfu and the HSPA9/Hsc20 chaperone complex. | 6 |
| 29309586 | 2018 | Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients. | 24 |
| 29211945 | 2018 | Regulation of human Nfu activity in Fe-S cluster delivery-characterization of the interaction between Nfu and the HSPA9/Hsc20 chaperone complex. | 6 |
| 29309586 | 2018 | Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients. | 24 |
| 28380382 | 2017 | A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III. | 50 |
| 28380382 | 2017 | A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III. | 50 |
| 27714045 | 2016 | Mammalian Fe-S proteins: definition of a consensus motif recognized by the co-chaperone HSC20. | 19 |
| 27714045 | 2016 | Mammalian Fe-S proteins: definition of a consensus motif recognized by the co-chaperone HSC20. | 19 |
| 23940031 | 2013 | Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU). | 29 |
| 23940031 | 2013 | Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU). | 29 |
| 20668094 | 2010 | Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis. | 46 |
Citation
Dessen P
HSCB (HscB mitochondrial iron-sulfur cluster cochaperone)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46982/hscb
