HSF4 (heat shock transcription factor 4)

2013-02-01 Affiliation

Identity

HGNC

HSF4

LOCATION

16q22.1

LOCUSID

3299

ALIAS

CTM,CTRCT5

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3299
MIM: 602438
HGNC: 5227
Ensembl: ENSG00000102878

Variants:

dbSNP: 3299
ClinVar: 3299
TCGA: ENSG00000102878
COSMIC: HSF4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000102878	ENST00000434833	E7EWW4
ENSG00000102878	ENST00000517685	E5RK26
ENSG00000102878	ENST00000517729	H0YBT7
ENSG00000102878	ENST00000517750	H0YBS6
ENSG00000102878	ENST00000519224	H0YC14
ENSG00000102878	ENST00000519601	H0YAU2
ENSG00000102878	ENST00000520304	H0YC39
ENSG00000102878	ENST00000520528	H0YAR7
ENSG00000102878	ENST00000521314	E5RHY0
ENSG00000102878	ENST00000521374	Q9ULV5
ENSG00000102878	ENST00000521374	A0A024R6X7
ENSG00000102878	ENST00000521624	E5RJV4
ENSG00000102878	ENST00000521916	H0YBG9
ENSG00000102878	ENST00000522295	E5RG51
ENSG00000102878	ENST00000523562	E7EWW4
ENSG00000102878	ENST00000584272	Q9ULV5

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
12089525	2002	Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract.	90
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15277496	2004	A homozygous splice mutation in the HSF4 gene is associated with an autosomal recessive congenital cataract.	45
15959809	2005	Locus heterogeneity in autosomal recessive congenital cataracts: linkage to 9q and germline HSF4 mutations.	32
15308659	2004	Developmentally dictated expression of heat shock factors: exclusive expression of HSF4 in the postnatal lens and its specific interaction with alphaB-crystallin heat shock promoter.	29
18941546	2008	Mutation screening of HSF4 in 150 age-related cataract patients.	19
16876512	2006	Novel HSF4 mutation causes congenital total white cataract in a Chinese family.	18
19014451	2008	A novel HSF4 gene mutation (p.R405X) causing autosomal recessive congenital cataracts in a large consanguineous family from Pakistan.	17
16552721	2006	Heat shock transcription factor (Hsf)-4b recruits Brg1 during the G1 phase of the cell cycle and regulates the expression of heat shock proteins.	15
23507146	2013	HSF4 regulates DLAD expression and promotes lens de-nucleation.	13

Citation

Dessen P

HSF4 (heat shock transcription factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53157/hsf4