HSP90AA1 (heat shock protein 90 alpha family class A member 1)

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HSP90AA1 (heat shock protein 90 alpha family class A member 1)

Identity

Alias_names	HSPC1
	HSPCA
	heat shock 90kD protein 1, alpha
	heat shock 90kDa protein 1, alpha
	heat shock protein 90kDa alpha (cytosolic), class A member 1
Alias_symbol (synonym)	Hsp89
	Hsp90
	FLJ31884
	HSP90N
Other alias	EL52
	HEL-S-65p
	HSP86
	HSP89A
	HSP90A
	HSPCAL1
	HSPCAL4
	HSPN
	Hsp103
	LAP-2
	LAP2
HGNC (Hugo)	HSP90AA1
LocusID (NCBI)	3320
Atlas_Id	40886
Location	14q32.31 [Link to chromosome band 14q32]
Location_base_pair	Starts at 102080738 and ends at 102087175 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

AP3D1 (19p13.3) / HSP90AA1 (14q32.31)	B4GALT5 (20q13.13) / HSP90AA1 (14q32.31)	BCL6 (3q27.3) / HSP90AA1 (14q32.31)
C1orf112 (1q24.2) / HSP90AA1 (14q32.31)	CDKAL1 (6p22.3) / HSP90AA1 (14q32.31)	EIF3B (7p22.3) / HSP90AA1 (14q32.31)
HIST1H2BK (6p22.1) / HSP90AA1 (14q32.31)	HLA-C (6p21.33) / HSP90AA1 (14q32.31)	HSP90AA1 (14q32.31) / ARHGAP32 (11q24.3)
HSP90AA1 (14q32.31) / BCL6 (3q27.3)	HSP90AA1 (14q32.31) / C14orf37 (14q23.1)	HSP90AA1 (14q32.31) / CALD1 (7q33)
HSP90AA1 (14q32.31) / CCDC91 (12p11.22)	HSP90AA1 (14q32.31) / DHX38 (16q22.2)	HSP90AA1 (14q32.31) / DYNC1H1 (14q32.31)
HSP90AA1 (14q32.31) / GNAI2 (3p21.31)	HSP90AA1 (14q32.31) / HSP90AA1 (14q32.31)	HSP90AA1 (14q32.31) / LINC00914 ()
HSP90AA1 (14q32.31) / MIR6723 (1p36.33)	HSP90AA1 (14q32.31) / MS4A6A (11q12.2)	HSP90AA1 (14q32.31) / NFRKB (11q24.3)
HSP90AA1 (14q32.31) / PAIP1 (5p12)	HSP90AA1 (14q32.31) / PCDHB5 (5q31.3)	HSP90AA1 (14q32.31) / RNF31 (14q12)
HSP90AA1 (14q32.31) / VPS13B (8q22.2)	LARS (5q32) / HSP90AA1 (14q32.31)	LOC442459 () / HSP90AA1 (14q32.31)
MALAT1 (11q13.1) / HSP90AA1 (14q32.31)	PAIP1 (5p12) / HSP90AA1 (14q32.31)	PHC2 (1p35.1) / HSP90AA1 (14q32.31)
PTPN12 (7q11.23) / HSP90AA1 (14q32.31)	RFC2 (7q11.23) / HSP90AA1 (14q32.31)	RPL38 (17q25.1) / HSP90AA1 (14q32.31)
SHFM1 (7q21.3) / HSP90AA1 (14q32.31)	CDKAL1 6p22.3 / HSP90AA1 14q32.31	HSP90AA1 14q32.31 RAGE
PHC2 1p35.1 / HSP90AA1 14q32.31

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]

t(3;14)(q27;q32) HSP90AA1/BCL6

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]

t(1;14)(p35;q32) PHC2/HSP90AA1
t(6;14)(p22;q32) CDKAL1/HSP90AA1
t(7;14)(q11;q32) PTPN12/HSP90AA1

External links

	Nomenclature
HGNC (Hugo)	HSP90AA1 5253
	Cards
Entrez_Gene (NCBI)	HSP90AA1 3320 heat shock protein 90 alpha family class A member 1
Aliases	EL52; HEL-S-65p; HSP86; HSP89A;
	HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; Hsp103; Hsp89; Hsp90; LAP-2; LAP2
GeneCards (Weizmann)	HSP90AA1
Ensembl hg19 (Hinxton)	ENSG00000080824 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000080824 [Gene_View] ENSG00000080824 [Sequence] chr14:102080738-102087175 [Contig_View] HSP90AA1 [Vega]
ICGC DataPortal	ENSG00000080824
TCGA cBioPortal	HSP90AA1
AceView (NCBI)	HSP90AA1
Genatlas (Paris)	HSP90AA1
WikiGenes	3320
SOURCE (Princeton)	HSP90AA1
Genetics Home Reference (NIH)	HSP90AA1
	Genomic and cartography
GoldenPath hg38 (UCSC)	HSP90AA1 - chr14:102080738-102087175 - 14q32.31 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	HSP90AA1 - 14q32.31 [Description] (hg19-Feb_2009)
GoldenPath	HSP90AA1 - 14q32.31 [CytoView hg19] HSP90AA1 - 14q32.31 [CytoView hg38]
ImmunoBase	ENSG00000080824
Mapping of homologs : NCBI	HSP90AA1 [Mapview hg19] HSP90AA1 [Mapview hg38]
OMIM	140571
	Gene and transcription
Genbank (Entrez)	AF028832 AI250920 AJ890082 AJ890083 AK056446
RefSeq transcript (Entrez)	NM_001017963 NM_005348
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	HSP90AA1
Cluster EST : Unigene	Hs.525600 [ NCBI ]
CGAP (NCI)	Hs.525600
Alternative Splicing Gallery	ENSG00000080824
Gene Expression	HSP90AA1 [ NCBI-GEO ] HSP90AA1 [ EBI - ARRAY_EXPRESS ] HSP90AA1 [ SEEK ] HSP90AA1 [ MEM ]
Gene Expression Viewer (FireBrowse)	HSP90AA1 [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevestigator	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	3320
GTEX Portal (Tissue expression)	HSP90AA1
Human Protein Atlas	ENSG00000080824-HSP90AA1 [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P07900 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P07900 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P07900
Splice isoforms : SwissVar	P07900
PhosPhoSitePlus	P07900
Domaine pattern : Prosite (Expaxy)	HSP90 (PS00298)
Domains : Interpro (EBI)	HATPase_C HATPase_C_sf Heat_shock_protein_90_CS HSP90_C Hsp90_fam Hsp90_N Ribosomal_S5_D2-typ_fold
Domain families : Pfam (Sanger)	HATPase_c (PF02518) HSP90 (PF00183)
Domain families : Pfam (NCBI)	pfam02518 pfam00183
Domain families : Smart (EMBL)	HATPase_c (SM00387)
Conserved Domain (NCBI)	HSP90AA1
DMDM Disease mutations	3320
Blocks (Seattle)	HSP90AA1
PDB (RSDB)	1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2FWY 2FWZ 2H55 2JJC 2K5B 2QF6 2QFO 2QG0 2QG2 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 3B24 3B25 3B26 3B27 3B28 3BM9 3BMY 3D0B 3EKO 3EKR 3FT5 3FT8 3HEK 3HHU 3HYY 3HYZ 3HZ1 3HZ5 3INW 3INX 3K97 3K98 3K99 3MNR 3O0I 3OW6 3OWB 3OWD 3Q6M 3Q6N 3QDD 3QTF 3R4M 3R4N 3R4O 3R4P 3R91 3R92 3RKZ 3RLP 3RLQ 3RLR 3T0H 3T0Z 3T10 3T1K 3T2S 3TUH 3VHA 3VHC 3VHD 3WHA 3WQ9 4AIF 4AWO 4AWP 4AWQ 4B7P 4BQG 4BQJ 4CGQ 4CGU 4CGV 4CGW 4CWF 4CWN 4CWO 4CWP 4CWQ 4CWR 4CWS 4CWT 4EEH 4EFT 4EFU 4EGH 4EGI 4EGK 4FCP 4FCQ 4FCR 4HY6 4JQL 4L8Z 4L90 4L91 4L93 4L94 4LWE 4LWF 4LWG 4LWH 4LWI 4NH7 4NH8 4O04 4O05 4O07 4O09 4O0B 4R3M 4U93 4W7T 4XIP 4XIQ 4XIR 4XIT 4YKQ 4YKR 4YKT 4YKU 4YKW 4YKX 4YKY 4YKZ 5CF0 5FNC 5FND 5FNF 5GGZ 5J20 5J27 5J2V 5J2X 5J64 5J6L 5J6M 5J6N 5J80 5J82 5J86 5J8M 5J8U 5J9X 5LNY 5LNZ 5LO0 5LO1 5LO5 5LO6 5LQ9 5LR1 5LR7 5LRL 5LRZ 5LS1 5M4E 5M4H 5T21
PDB Europe	1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2FWY 2FWZ 2H55 2JJC 2K5B 2QF6 2QFO 2QG0 2QG2 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 3B24 3B25 3B26 3B27 3B28 3BM9 3BMY 3D0B 3EKO 3EKR 3FT5 3FT8 3HEK 3HHU 3HYY 3HYZ 3HZ1 3HZ5 3INW 3INX 3K97 3K98 3K99 3MNR 3O0I 3OW6 3OWB 3OWD 3Q6M 3Q6N 3QDD 3QTF 3R4M 3R4N 3R4O 3R4P 3R91 3R92 3RKZ 3RLP 3RLQ 3RLR 3T0H 3T0Z 3T10 3T1K 3T2S 3TUH 3VHA 3VHC 3VHD 3WHA 3WQ9 4AIF 4AWO 4AWP 4AWQ 4B7P 4BQG 4BQJ 4CGQ 4CGU 4CGV 4CGW 4CWF 4CWN 4CWO 4CWP 4CWQ 4CWR 4CWS 4CWT 4EEH 4EFT 4EFU 4EGH 4EGI 4EGK 4FCP 4FCQ 4FCR 4HY6 4JQL 4L8Z 4L90 4L91 4L93 4L94 4LWE 4LWF 4LWG 4LWH 4LWI 4NH7 4NH8 4O04 4O05 4O07 4O09 4O0B 4R3M 4U93 4W7T 4XIP 4XIQ 4XIR 4XIT 4YKQ 4YKR 4YKT 4YKU 4YKW 4YKX 4YKY 4YKZ 5CF0 5FNC 5FND 5FNF 5GGZ 5J20 5J27 5J2V 5J2X 5J64 5J6L 5J6M 5J6N 5J80 5J82 5J86 5J8M 5J8U 5J9X 5LNY 5LNZ 5LO0 5LO1 5LO5 5LO6 5LQ9 5LR1 5LR7 5LRL 5LRZ 5LS1 5M4E 5M4H 5T21
PDB (PDBSum)	1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2FWY 2FWZ 2H55 2JJC 2K5B 2QF6 2QFO 2QG0 2QG2 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 3B24 3B25 3B26 3B27 3B28 3BM9 3BMY 3D0B 3EKO 3EKR 3FT5 3FT8 3HEK 3HHU 3HYY 3HYZ 3HZ1 3HZ5 3INW 3INX 3K97 3K98 3K99 3MNR 3O0I 3OW6 3OWB 3OWD 3Q6M 3Q6N 3QDD 3QTF 3R4M 3R4N 3R4O 3R4P 3R91 3R92 3RKZ 3RLP 3RLQ 3RLR 3T0H 3T0Z 3T10 3T1K 3T2S 3TUH 3VHA 3VHC 3VHD 3WHA 3WQ9 4AIF 4AWO 4AWP 4AWQ 4B7P 4BQG 4BQJ 4CGQ 4CGU 4CGV 4CGW 4CWF 4CWN 4CWO 4CWP 4CWQ 4CWR 4CWS 4CWT 4EEH 4EFT 4EFU 4EGH 4EGI 4EGK 4FCP 4FCQ 4FCR 4HY6 4JQL 4L8Z 4L90 4L91 4L93 4L94 4LWE 4LWF 4LWG 4LWH 4LWI 4NH7 4NH8 4O04 4O05 4O07 4O09 4O0B 4R3M 4U93 4W7T 4XIP 4XIQ 4XIR 4XIT 4YKQ 4YKR 4YKT 4YKU 4YKW 4YKX 4YKY 4YKZ 5CF0 5FNC 5FND 5FNF 5GGZ 5J20 5J27 5J2V 5J2X 5J64 5J6L 5J6M 5J6N 5J80 5J82 5J86 5J8M 5J8U 5J9X 5LNY 5LNZ 5LO0 5LO1 5LO5 5LO6 5LQ9 5LR1 5LR7 5LRL 5LRZ 5LS1 5M4E 5M4H 5T21
PDB (IMB)	1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2FWY 2FWZ 2H55 2JJC 2K5B 2QF6 2QFO 2QG0 2QG2 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 3B24 3B25 3B26 3B27 3B28 3BM9 3BMY 3D0B 3EKO 3EKR 3FT5 3FT8 3HEK 3HHU 3HYY 3HYZ 3HZ1 3HZ5 3INW 3INX 3K97 3K98 3K99 3MNR 3O0I 3OW6 3OWB 3OWD 3Q6M 3Q6N 3QDD 3QTF 3R4M 3R4N 3R4O 3R4P 3R91 3R92 3RKZ 3RLP 3RLQ 3RLR 3T0H 3T0Z 3T10 3T1K 3T2S 3TUH 3VHA 3VHC 3VHD 3WHA 3WQ9 4AIF 4AWO 4AWP 4AWQ 4B7P 4BQG 4BQJ 4CGQ 4CGU 4CGV 4CGW 4CWF 4CWN 4CWO 4CWP 4CWQ 4CWR 4CWS 4CWT 4EEH 4EFT 4EFU 4EGH 4EGI 4EGK 4FCP 4FCQ 4FCR 4HY6 4JQL 4L8Z 4L90 4L91 4L93 4L94 4LWE 4LWF 4LWG 4LWH 4LWI 4NH7 4NH8 4O04 4O05 4O07 4O09 4O0B 4R3M 4U93 4W7T 4XIP 4XIQ 4XIR 4XIT 4YKQ 4YKR 4YKT 4YKU 4YKW 4YKX 4YKY 4YKZ 5CF0 5FNC 5FND 5FNF 5GGZ 5J20 5J27 5J2V 5J2X 5J64 5J6L 5J6M 5J6N 5J80 5J82 5J86 5J8M 5J8U 5J9X 5LNY 5LNZ 5LO0 5LO1 5LO5 5LO6 5LQ9 5LR1 5LR7 5LRL 5LRZ 5LS1 5M4E 5M4H 5T21
Structural Biology KnowledgeBase	1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2FWY 2FWZ 2H55 2JJC 2K5B 2QF6 2QFO 2QG0 2QG2 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 3B24 3B25 3B26 3B27 3B28 3BM9 3BMY 3D0B 3EKO 3EKR 3FT5 3FT8 3HEK 3HHU 3HYY 3HYZ 3HZ1 3HZ5 3INW 3INX 3K97 3K98 3K99 3MNR 3O0I 3OW6 3OWB 3OWD 3Q6M 3Q6N 3QDD 3QTF 3R4M 3R4N 3R4O 3R4P 3R91 3R92 3RKZ 3RLP 3RLQ 3RLR 3T0H 3T0Z 3T10 3T1K 3T2S 3TUH 3VHA 3VHC 3VHD 3WHA 3WQ9 4AIF 4AWO 4AWP 4AWQ 4B7P 4BQG 4BQJ 4CGQ 4CGU 4CGV 4CGW 4CWF 4CWN 4CWO 4CWP 4CWQ 4CWR 4CWS 4CWT 4EEH 4EFT 4EFU 4EGH 4EGI 4EGK 4FCP 4FCQ 4FCR 4HY6 4JQL 4L8Z 4L90 4L91 4L93 4L94 4LWE 4LWF 4LWG 4LWH 4LWI 4NH7 4NH8 4O04 4O05 4O07 4O09 4O0B 4R3M 4U93 4W7T 4XIP 4XIQ 4XIR 4XIT 4YKQ 4YKR 4YKT 4YKU 4YKW 4YKX 4YKY 4YKZ 5CF0 5FNC 5FND 5FNF 5GGZ 5J20 5J27 5J2V 5J2X 5J64 5J6L 5J6M 5J6N 5J80 5J82 5J86 5J8M 5J8U 5J9X 5LNY 5LNZ 5LO0 5LO1 5LO5 5LO6 5LQ9 5LR1 5LR7 5LRL 5LRZ 5LS1 5M4E 5M4H 5T21
SCOP (Structural Classification of Proteins)	1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2FWY 2FWZ 2H55 2JJC 2K5B 2QF6 2QFO 2QG0 2QG2 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 3B24 3B25 3B26 3B27 3B28 3BM9 3BMY 3D0B 3EKO 3EKR 3FT5 3FT8 3HEK 3HHU 3HYY 3HYZ 3HZ1 3HZ5 3INW 3INX 3K97 3K98 3K99 3MNR 3O0I 3OW6 3OWB 3OWD 3Q6M 3Q6N 3QDD 3QTF 3R4M 3R4N 3R4O 3R4P 3R91 3R92 3RKZ 3RLP 3RLQ 3RLR 3T0H 3T0Z 3T10 3T1K 3T2S 3TUH 3VHA 3VHC 3VHD 3WHA 3WQ9 4AIF 4AWO 4AWP 4AWQ 4B7P 4BQG 4BQJ 4CGQ 4CGU 4CGV 4CGW 4CWF 4CWN 4CWO 4CWP 4CWQ 4CWR 4CWS 4CWT 4EEH 4EFT 4EFU 4EGH 4EGI 4EGK 4FCP 4FCQ 4FCR 4HY6 4JQL 4L8Z 4L90 4L91 4L93 4L94 4LWE 4LWF 4LWG 4LWH 4LWI 4NH7 4NH8 4O04 4O05 4O07 4O09 4O0B 4R3M 4U93 4W7T 4XIP 4XIQ 4XIR 4XIT 4YKQ 4YKR 4YKT 4YKU 4YKW 4YKX 4YKY 4YKZ 5CF0 5FNC 5FND 5FNF 5GGZ 5J20 5J27 5J2V 5J2X 5J64 5J6L 5J6M 5J6N 5J80 5J82 5J86 5J8M 5J8U 5J9X 5LNY 5LNZ 5LO0 5LO1 5LO5 5LO6 5LQ9 5LR1 5LR7 5LRL 5LRZ 5LS1 5M4E 5M4H 5T21
CATH (Classification of proteins structures)	1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2FWY 2FWZ 2H55 2JJC 2K5B 2QF6 2QFO 2QG0 2QG2 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 3B24 3B25 3B26 3B27 3B28 3BM9 3BMY 3D0B 3EKO 3EKR 3FT5 3FT8 3HEK 3HHU 3HYY 3HYZ 3HZ1 3HZ5 3INW 3INX 3K97 3K98 3K99 3MNR 3O0I 3OW6 3OWB 3OWD 3Q6M 3Q6N 3QDD 3QTF 3R4M 3R4N 3R4O 3R4P 3R91 3R92 3RKZ 3RLP 3RLQ 3RLR 3T0H 3T0Z 3T10 3T1K 3T2S 3TUH 3VHA 3VHC 3VHD 3WHA 3WQ9 4AIF 4AWO 4AWP 4AWQ 4B7P 4BQG 4BQJ 4CGQ 4CGU 4CGV 4CGW 4CWF 4CWN 4CWO 4CWP 4CWQ 4CWR 4CWS 4CWT 4EEH 4EFT 4EFU 4EGH 4EGI 4EGK 4FCP 4FCQ 4FCR 4HY6 4JQL 4L8Z 4L90 4L91 4L93 4L94 4LWE 4LWF 4LWG 4LWH 4LWI 4NH7 4NH8 4O04 4O05 4O07 4O09 4O0B 4R3M 4U93 4W7T 4XIP 4XIQ 4XIR 4XIT 4YKQ 4YKR 4YKT 4YKU 4YKW 4YKX 4YKY 4YKZ 5CF0 5FNC 5FND 5FNF 5GGZ 5J20 5J27 5J2V 5J2X 5J64 5J6L 5J6M 5J6N 5J80 5J82 5J86 5J8M 5J8U 5J9X 5LNY 5LNZ 5LO0 5LO1 5LO5 5LO6 5LQ9 5LR1 5LR7 5LRL 5LRZ 5LS1 5M4E 5M4H 5T21
Superfamily	P07900
Human Protein Atlas [tissue]	ENSG00000080824-HSP90AA1 [tissue]
Peptide Atlas	P07900
HPRD	00777
IPI	IPI00784295 IPI00382470 IPI00910046 IPI00604607 IPI01024910 IPI01024776 IPI01025664
	Protein Interaction databases
DIP (DOE-UCLA)	P07900
IntAct (EBI)	P07900
FunCoup	ENSG00000080824
BioGRID	HSP90AA1
STRING (EMBL)	HSP90AA1
ZODIAC	HSP90AA1
	Ontologies - Pathways
QuickGO	P07900
Ontology : AmiGO	G2/M transition of mitotic cell cycle nucleotide binding positive regulation of protein phosphorylation RNA binding protein binding ATP binding ATP binding ATP binding extracellular region nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm cytoplasm cytosol cytosol cytosol plasma membrane plasma membrane protein folding mitochondrial transport receptor-mediated endocytosis response to unfolded protein telomere maintenance via telomerase signal transduction response to heat response to cold cell surface regulation of G2/M transition of mitotic cell cycle membrane ATPase activity cytokine-mediated signaling pathway central nervous system neuron axonogenesis MHC class II protein complex binding establishment of cell polarity nitric-oxide synthase regulator activity TPR domain binding TPR domain binding regulation of protein ubiquitination ubiquitin protein ligase binding positive regulation of protein polymerization protein-containing complex protein-containing complex positive regulation of peptidyl-serine phosphorylation cellular response to heat secretory granule lumen Fc-gamma receptor signaling pathway involved in phagocytosis ERBB2 signaling pathway protein refolding melanosome ATPase activity, coupled identical protein binding identical protein binding protein homodimerization activity protein homodimerization activity histone deacetylase binding neuronal cell body neuronal cell body lysosomal lumen myelin sheath regulation of protein complex assembly neutrophil degranulation protein unfolding dendritic growth cone axonal growth cone protein import into mitochondrial outer membrane positive regulation of nitric oxide biosynthetic process response to antibiotic vascular endothelial growth factor receptor signaling pathway tau protein binding perinuclear region of cytoplasm perinuclear region of cytoplasm axon extension protein stabilization protein stabilization protein stabilization regulation of nitric-oxide synthase activity GTPase binding unfolded protein binding chaperone-mediated protein complex assembly cofactor metabolic process positive regulation of protein kinase B signaling positive regulation of telomerase activity chaperone-mediated autophagy extracellular exosome DNA polymerase binding endocytic vesicle lumen scaffold protein binding ciliary basal body-plasma membrane docking disordered domain specific binding disordered domain specific binding regulation of cellular response to heat positive regulation of tau-protein kinase activity positive regulation of cellular protein catabolic process regulation of cellular protein localization ficolin-1-rich granule lumen telomerase holoenzyme complex assembly protein tyrosine kinase binding
Ontology : EGO-EBI	G2/M transition of mitotic cell cycle nucleotide binding positive regulation of protein phosphorylation RNA binding protein binding ATP binding ATP binding ATP binding extracellular region nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm cytoplasm cytosol cytosol cytosol plasma membrane plasma membrane protein folding mitochondrial transport receptor-mediated endocytosis response to unfolded protein telomere maintenance via telomerase signal transduction response to heat response to cold cell surface regulation of G2/M transition of mitotic cell cycle membrane ATPase activity cytokine-mediated signaling pathway central nervous system neuron axonogenesis MHC class II protein complex binding establishment of cell polarity nitric-oxide synthase regulator activity TPR domain binding TPR domain binding regulation of protein ubiquitination ubiquitin protein ligase binding positive regulation of protein polymerization protein-containing complex protein-containing complex positive regulation of peptidyl-serine phosphorylation cellular response to heat secretory granule lumen Fc-gamma receptor signaling pathway involved in phagocytosis ERBB2 signaling pathway protein refolding melanosome ATPase activity, coupled identical protein binding identical protein binding protein homodimerization activity protein homodimerization activity histone deacetylase binding neuronal cell body neuronal cell body lysosomal lumen myelin sheath regulation of protein complex assembly neutrophil degranulation protein unfolding dendritic growth cone axonal growth cone protein import into mitochondrial outer membrane positive regulation of nitric oxide biosynthetic process response to antibiotic vascular endothelial growth factor receptor signaling pathway tau protein binding perinuclear region of cytoplasm perinuclear region of cytoplasm axon extension protein stabilization protein stabilization protein stabilization regulation of nitric-oxide synthase activity GTPase binding unfolded protein binding chaperone-mediated protein complex assembly cofactor metabolic process positive regulation of protein kinase B signaling positive regulation of telomerase activity chaperone-mediated autophagy extracellular exosome DNA polymerase binding endocytic vesicle lumen scaffold protein binding ciliary basal body-plasma membrane docking disordered domain specific binding disordered domain specific binding regulation of cellular response to heat positive regulation of tau-protein kinase activity positive regulation of cellular protein catabolic process regulation of cellular protein localization ficolin-1-rich granule lumen telomerase holoenzyme complex assembly protein tyrosine kinase binding
Pathways : KEGG	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Antigen processing and presentation NOD-like receptor signaling pathway Progesterone-mediated oocyte maturation Estrogen signaling pathway Pathways in cancer Prostate cancer
NDEx Network	HSP90AA1
Atlas of Cancer Signalling Network	HSP90AA1
Wikipedia pathways	HSP90AA1
	Orthology - Evolution
OrthoDB	3320
GeneTree (enSembl)	ENSG00000080824
Phylogenetic Trees/Animal Genes : TreeFam	HSP90AA1
HOGENOM	P07900
Homologs : HomoloGene	HSP90AA1
Homology/Alignments : Family Browser (UCSC)	HSP90AA1
	Gene fusions - Rearrangements
Fusion : Mitelman	CDKAL1/HSP90AA1 [6p22.3/14q32.31] [t(6;14)(p22;q32)]
Fusion : Mitelman	HSP90AA1/BCL6 [14q32.31/3q27.3] [t(3;14)(q27;q32)]
Fusion : Mitelman	PHC2/HSP90AA1 [1p35.1/14q32.31] [t(1;14)(p35;q32)]
Fusion : Mitelman	PTPN12/HSP90AA1 [7q11.23/14q32.31] [t(7;14)(q11;q32)]
Fusion Portal	CDKAL1 6p22.3 HSP90AA1 14q32.31 BRCA
Fusion Portal	HSP90AA1 14q32.31 RAGE LUSC
Fusion Portal	PHC2 1p35.1 HSP90AA1 14q32.31 PRAD
Fusion : Quiver	HSP90AA1
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	HSP90AA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	HSP90AA1
dbVar	HSP90AA1
ClinVar	HSP90AA1
1000_Genomes	HSP90AA1
Exome Variant Server	HSP90AA1
ExAC (Exome Aggregation Consortium)	ENSG00000080824
GNOMAD Browser	ENSG00000080824
Varsome Browser	HSP90AA1
Genetic variants : HAPMAP	3320
Genomic Variants (DGV)	HSP90AA1 [DGVbeta]
DECIPHER	HSP90AA1 [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	HSP90AA1
	Mutations
ICGC Data Portal	HSP90AA1
TCGA Data Portal	HSP90AA1
Broad Tumor Portal	HSP90AA1
OASIS Portal	HSP90AA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	HSP90AA1 [overview] [genome browser] [tissue] [distribution]
Somatic Mutations in Cancer : COSMIC3D	HSP90AA1
Mutations and Diseases : HGMD	HSP90AA1
intOGen Portal	HSP90AA1
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
BioMuta	search HSP90AA1
DgiDB (Drug Gene Interaction Database)	HSP90AA1
DoCM (Curated mutations)	HSP90AA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	HSP90AA1 (select a term)
intoGen	HSP90AA1
Cancer3D	HSP90AA1(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	140571
Orphanet
DisGeNET	HSP90AA1
Medgen	HSP90AA1
Genetic Testing Registry	HSP90AA1
NextProt	P07900 [Medical]
TSGene	3320
GENETests	HSP90AA1
Target Validation	HSP90AA1
Huge Navigator	HSP90AA1 [HugePedia]
snp3D : Map Gene to Disease	3320
BioCentury BCIQ	HSP90AA1
ClinGen	HSP90AA1
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	3320
Chemical/Pharm GKB Gene	PA29519
Clinical trial	HSP90AA1
	Miscellaneous
canSAR (ICR)	HSP90AA1 (select the gene name)
DataMed Index	HSP90AA1
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	HSP90AA1
EVEX	HSP90AA1
GoPubMed	HSP90AA1
iHOP	HSP90AA1

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Wed Nov 13 17:47:29 CET 2019

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Atlas of Genetics and Cytogenetics in Oncology and Haematology

HSP90AA1 (heat shock protein 90 alpha family class A member 1)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute