HSP90AB1 (heat shock protein 90 alpha family class B member 1)

2003-08-01  

Identity

HGNC
LOCATION
6p21.1
LOCUSID
ALIAS
D6S182,HSP84,HSP90B,HSPC2,HSPCB
FUSION GENES

Other Information

Locus ID:

NCBI: 3326
MIM: 140572
HGNC: 5258
Ensembl: ENSG00000096384

Variants:

dbSNP: 3326
ClinVar: 3326
TCGA: ENSG00000096384
COSMIC: HSP90AB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000096384ENST00000353801P08238
ENSG00000096384ENST00000353801A0A024RD80
ENSG00000096384ENST00000371554P08238
ENSG00000096384ENST00000371554A0A024RD80
ENSG00000096384ENST00000371646P08238
ENSG00000096384ENST00000371646A0A024RD80
ENSG00000096384ENST00000620073P08238
ENSG00000096384ENST00000620073A0A024RD80

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Progesterone-mediated oocyte maturationKEGGko04914
Prostate cancerKEGGko05215
Antigen processing and presentationKEGGhsa04612
Pathways in cancerKEGGhsa05200
Prostate cancerKEGGhsa05215
Progesterone-mediated oocyte maturationKEGGhsa04914
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Uptake and actions of bacterial toxinsREACTOMER-HSA-5339562
Uptake and function of diphtheria toxinREACTOMER-HSA-5336415
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACTOMER-HSA-168643
InflammasomesREACTOMER-HSA-622312
The NLRP3 inflammasomeREACTOMER-HSA-844456
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Sema3A PAK dependent Axon repulsionREACTOMER-HSA-399954
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1 activationREACTOMER-HSA-3371511
HSF1-dependent transactivationREACTOMER-HSA-3371571
Attenuation phaseREACTOMER-HSA-3371568
The role of GTSE1 in G2/M progression after G2 checkpointREACTOMER-HSA-8852276
Neutrophil degranulationREACTOMER-HSA-6798695
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Aryl hydrocarbon receptor signallingREACTOMER-HSA-8937144
IL-17 signaling pathwayKEGGko04657
Fluid shear stress and atherosclerosisKEGGko05418
IL-17 signaling pathwayKEGGhsa04657
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130232992bevacizumabChemicalClinicalAnnotationassociatedPD29871907
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD29871907

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
245814952014Hsp90-Tau complex reveals molecular basis for specificity in chaperone action.73
198582142009Characterization of celastrol to inhibit hsp90 and cdc37 interaction.66
184007512008Conserved conformational changes in the ATPase cycle of human Hsp90.56
192548102009The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids.39
185912562008Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias.34
248800802014SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation.34
199963132010Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23.32
229294012012Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients.30
155813632004Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex.29

Citation

Dessen P

HSP90AB1 (heat shock protein 90 alpha family class B member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40887/hsp90ab1