HSPA1L (heat shock protein family A (Hsp70) member 1 like)

2003-08-01 Affiliation

Identity

HGNC

HSPA1L

LOCATION

6p21.33

LOCUSID

3305

ALIAS

HSP70-1L,HSP70-HOM,HSP70T,hum70t

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3305
MIM: 140559
HGNC: 5234
Ensembl: ENSG00000204390

Variants:

dbSNP: 3305
ClinVar: 3305
TCGA: ENSG00000204390
COSMIC: HSPA1L

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204390	ENST00000375654	P34931
ENSG00000204390	ENST00000375654	A0A1U9X7W7

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Antigen processing and presentation	KEGG	ko04612
MAPK signaling pathway	KEGG	hsa04010
Antigen processing and presentation	KEGG	hsa04612
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Spliceosome	KEGG	ko03040
Spliceosome	KEGG	hsa03040
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Spliceosome, Prp19/CDC5L complex	KEGG	hsa_M00353
Spliceosome, 35S U5-snRNP	KEGG	hsa_M00355
Legionellosis	KEGG	ko05134
Legionellosis	KEGG	hsa05134
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Spliceosome, Prp19/CDC5L complex	KEGG	M00353
Spliceosome, 35S U5-snRNP	KEGG	M00355
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
HSF1-dependent transactivation	REACTOME	R-HSA-3371571
Attenuation phase	REACTOME	R-HSA-3371568
Regulation of HSF1-mediated heat shock response	REACTOME	R-HSA-3371453
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA444065	Epilepsy	Disease	ClinicalAnnotation	associated		PD	16538175
PA448785	carbamazepine	Chemical	ClinicalAnnotation	associated		PD	16538175

References

Pubmed ID	Year	Title	Citations
16538176	2006	Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.	112
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19851445	2009	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	51
14605873	2004	Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease.	31
18818748	2008	Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.	31
19527514	2009	Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.	31
20069064	2010	Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts.	29
17601350	2007	A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.	27
19019335	2009	Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.	26
19789190	2009	A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.	23

Citation

Dessen P

HSPA1L (heat shock protein family A (Hsp70) member 1 like)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40873/hspa1l