HSPA4 (heat shock protein family A (Hsp70) member 4)

2003-06-01  

Identity

HGNC
LOCATION
5q31.1
LOCUSID
ALIAS
APG-2,HEL-S-5a,HS24/P52,HSPH2,RY,hsp70,hsp70RY
FUSION GENES

Other Information

Locus ID:

NCBI: 3308
MIM: 601113
HGNC: 5237
Ensembl: ENSG00000170606

Variants:

dbSNP: 3308
ClinVar: 3308
TCGA: ENSG00000170606
COSMIC: HSPA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170606ENST00000304858P34932
ENSG00000170606ENST00000615899A0A087WTS8
ENSG00000170606ENST00000617074A0A087WYC1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Antigen processing and presentationKEGGko04612
Tight junctionKEGGhsa04530
Antigen processing and presentationKEGGhsa04612
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125267922003Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70.239
240124262013Hsp70 chaperone dynamics and molecular mechanism.138
183222432008Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages.135
208762152011Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.124
220226002011The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system.115
268653652016The human HSP70 family of chaperones: where do we stand?94
239732232013The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.92
185504092008Structure of the Hsp110:Hsc70 nucleotide exchange machine.89
268749232016Heat Shock Proteins Promote Cancer: It's a Protection Racket.71
237375322013Hsp110 is a bona fide chaperone using ATP to unfold stable misfolded polypeptides and reciprocally collaborate with Hsp70 to solubilize protein aggregates.64

Citation

Dessen P

HSPA4 (heat shock protein family A (Hsp70) member 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40875/hspa4