HSPA4L (heat shock protein family A (Hsp70) member 4 like)

2007-04-01  

Identity

HGNC
LOCATION
4q28.1
LOCUSID
ALIAS
APG-1,APG1,HSPH3,Osp94
FUSION GENES

Other Information

Locus ID:

NCBI: 22824
HGNC: 17041
Ensembl: ENSG00000164070

Variants:

dbSNP: 22824
ClinVar: 22824
TCGA: ENSG00000164070
COSMIC: HSPA4L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164070ENST00000296464O95757
ENSG00000164070ENST00000296464A0A140VKE7
ENSG00000164070ENST00000505726E9PDE8
ENSG00000164070ENST00000508549D6RJ96
ENSG00000164070ENST00000508776O95757
ENSG00000164070ENST00000508776A0A140VKE7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
219465392011Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis.39
235092522013Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm.30
240916762013Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110.29
264860822015The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L.21
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
129529232003Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells.9
306378422019Decreased expression of heat shock protein A4L in spermatozoa is positively related to poor human sperm quality.1

Citation

Dessen P

HSPA4L (heat shock protein family A (Hsp70) member 4 like)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47179/hspa4l