HSPA6 (heat shock protein family A (Hsp70) member 6)

2003-06-01 Affiliation

Identity

HGNC

HSPA6

LOCATION

1q23.3

LOCUSID

3310

ALIAS

HSP70B

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3310
MIM: 140555
HGNC: 5239
Ensembl: ENSG00000173110

Variants:

dbSNP: 3310
ClinVar: 3310
TCGA: ENSG00000173110
COSMIC: HSPA6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000173110	ENST00000309758	P17066
ENSG00000173110	ENST00000309758	A0A384NKX5

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Antigen processing and presentation	KEGG	ko04612
MAPK signaling pathway	KEGG	hsa04010
Antigen processing and presentation	KEGG	hsa04612
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Spliceosome	KEGG	ko03040
Spliceosome	KEGG	hsa03040
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Spliceosome, Prp19/CDC5L complex	KEGG	hsa_M00353
Spliceosome, 35S U5-snRNP	KEGG	hsa_M00355
Legionellosis	KEGG	ko05134
Legionellosis	KEGG	hsa05134
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Spliceosome, Prp19/CDC5L complex	KEGG	M00353
Spliceosome, 35S U5-snRNP	KEGG	M00355
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
Regulation of HSF1-mediated heat shock response	REACTOME	R-HSA-3371453
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
25798051	2015	Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma.	34
18229458	2007	Hsp70B' regulation and function.	32
18818748	2008	Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.	31
19527514	2009	Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.	31
17601350	2007	A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.	27
19019335	2009	Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.	26
19074885	2008	Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.	25
18977241	2008	Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.	20
19423540	2009	Common variation in genes related to innate immunity and risk of adult glioma.	19
18579131	2008	Hsp70B' and Hsp72 form a complex in stressed human colon cells and each contributes to cytoprotection.	18

Citation

Dessen P

HSPA6 (heat shock protein family A (Hsp70) member 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40877/hspa6