HSPA9 (heat shock protein family A (Hsp70) member 9)

2003-02-01  

Identity

HGNC
HSPA9
LOCATION
5q31.2
LOCUSID
3313
ALIAS
CRP40,CSA,EVPLS,GRP-75,GRP75,HEL-S-124m,HSPA9B,MOT,MOT2,MTHSP75,PBP74,SAAN,SIDBA4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3313
MIM: 600548
HGNC: 5244
Ensembl: ENSG00000113013

Variants:

dbSNP: 3313
ClinVar: 3313
TCGA: ENSG00000113013
COSMIC: HSPA9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113013ENST00000297185P38646
ENSG00000113013ENST00000297185A0A384P5G6
ENSG00000113013ENST00000501917A0A3B3ITN1
ENSG00000113013ENST00000504810D6RJI2
ENSG00000113013ENST00000504902H0Y8K0
ENSG00000113013ENST00000505110D6RDH7
ENSG00000113013ENST00000507115D6RCD7
ENSG00000113013ENST00000507886D6RA73
ENSG00000113013ENST00000512328H0Y8S0
ENSG00000113013ENST00000523929H0YBG6
ENSG00000113013ENST00000649578A0A3B3ITI4

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Metabolism of proteinsREACTOMER-HSA-392499
Mitochondrial protein importREACTOMER-HSA-1268020
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199401512010Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.91
164252582006Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.62
212338472011Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy.53
161769312005Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides.48
208176352010Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.48
119004852002Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein.45
179342172008Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence.39
220130422012Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release.34
182192562008Mortalin: a protein associated with progression of Parkinson disease?32
159579802005Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60.28

Citation

Dessen P

HSPA9 (heat shock protein family A (Hsp70) member 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40879/hspa9