HSPB3 (heat shock protein family B (small) member 3)

2007-04-01  

Identity

HGNC
HSPB3
LOCATION
5q11.2
LOCUSID
8988
ALIAS
DHMN2C,HMN2C,HSPL27

Other Information

Locus ID:

NCBI: 8988
MIM: 604624
HGNC: 5248
Ensembl: ENSG00000169271

Variants:

dbSNP: 8988
ClinVar: 8988
TCGA: ENSG00000169271
COSMIC: HSPB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169271ENST00000302005Q12988
ENSG00000169271ENST00000302005Q6ICS9

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
162258512005Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3.26
201426172010Mutant small heat shock protein B3 causes motor neuropathy: utility of a candidate gene approach.24
226106612012Structural aspects and chaperone activity of human HspB3: role of the "C-terminal extension".6
281811532017An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8.6
275677402016HSPB3 protein is expressed in motoneurons and induces their survival after lesion-induced degeneration.5
293413432018Small heat shock protein B3 (HSPB3) mutation in an axonal Charcot-Marie-Tooth disease family.4
317096192020Heat shock protein beta 3 (HSPB3) is an unfavorable molecular biomarker in colorectal adenocarcinoma.1

Citation

Dessen P

HSPB3 (heat shock protein family B (small) member 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47490/hspb3