HTN3 (histatin 3)

2010-11-01  

Identity

HGNC
HTN3
LOCATION
4q13.3
LOCUSID
3347
ALIAS
HIS2,HTN2,HTN5,PB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3347
MIM: 142702
HGNC: 5284
Ensembl: ENSG00000205649

Variants:

dbSNP: 3347
ClinVar: 3347
TCGA: ENSG00000205649
COSMIC: HTN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205649ENST00000381057X6RAH8
ENSG00000205649ENST00000526767P15516
ENSG00000205649ENST00000530128P15516

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
127612192003Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5.57
186502432008Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay.38
249514392014How does it kill?: understanding the candidacidal mechanism of salivary histatin 5.37
204872762010Salivary histatin 5 internalization by translocation, but not endocytosis, is required for fungicidal activity in Candida albicans.32
152720242004A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
118169732001Killing of Candida albicans by histatin 5: cellular uptake and energy requirement.26
182306842008Human antimicrobial peptide histatin 5 is a cell-penetrating peptide targeting mitochondrial ATP synthesis in Leishmania.26
179999632008The P-113 fragment of histatin 5 requires a specific peptide sequence for intracellular translocation in Candida albicans, which is independent of cell wall binding.24
220339182011Histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins.23

Citation

Dessen P

HTN3 (histatin 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-11-01

Online version: http://atlasgeneticsoncology.org/gene/51767/htn3