HTR1A (5-hydroxytryptamine receptor 1A)

2012-06-01 Affiliation

Identity

HGNC

HTR1A

LOCATION

5q12.3

LOCUSID

3350

ALIAS

5-HT-1A,5-HT1A,5HT1a,ADRB2RL1,ADRBRL1,G-21,PFMCD

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3350
MIM: 109760
HGNC: 5286
Ensembl: ENSG00000178394

Variants:

dbSNP: 3350
ClinVar: 3350
TCGA: ENSG00000178394
COSMIC: HTR1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000178394	ENST00000323865	P08908
ENSG00000178394	ENST00000323865	Q5ZGX3
ENSG00000178394	ENST00000506598	D6RA34

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Taste transduction	KEGG	ko04742
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Taste transduction	KEGG	hsa04742
Serotonergic synapse	KEGG	hsa04726
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Serotonin receptors	REACTOME	R-HSA-390666
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA162565877	amisulpride	Chemical	ClinicalAnnotation	associated	PD	22120873
PA164713257	Selective serotonin reuptake inhibitors	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation	associated	PD	18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030, 24930681
PA164752812	milnacipran	Chemical	ClinicalAnnotation	associated	PD	18484082
PA166129557	lurasidone	Chemical	ClinicalAnnotation	associated	PD	31636356
PA172	GNAI1	Gene	Pathway	associated		19741567
PA173	GNAI3	Gene	Pathway	associated		19741567
PA24347	GNAI2	Gene	Pathway	associated		19741567
PA446876	Substance-Related Disorders	Disease	ClinicalAnnotation	associated	PD	19747927
PA447207	Depressive Disorder	Disease	ClinicalAnnotation	associated	PD	18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030
PA447212	Panic Disorder	Disease	ClinicalAnnotation	associated	PD	19590397, 19800133, 21688171
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated	PD	22120873, 25560469, 31636356
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD	16302021, 18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030
PA449061	clozapine	Chemical	ClinicalAnnotation	associated	PD	25560469
PA449673	fluoxetine	Chemical	ClinicalAnnotation	associated	PD	16302021, 19590397
PA449690	fluvoxamine	Chemical	ClinicalAnnotation	associated	PD	18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030
PA450403	methamphetamine	Chemical	ClinicalAnnotation	associated	PD	19747927
PA450688	olanzapine	Chemical	ClinicalAnnotation	associated	PD	22120873
PA450801	paroxetine	Chemical	ClinicalAnnotation	associated	PD	18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030
PA451201	quetiapine	Chemical	ClinicalAnnotation	associated	PD	22120873
PA451257	risperidone	Chemical	ClinicalAnnotation	associated	PD	22120873
PA451333	sertraline	Chemical	ClinicalAnnotation	associated	PD	18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030
PA452229	antidepressants	Chemical	ClinicalAnnotation	associated	PD	18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030
PA452233	antipsychotics	Chemical	ClinicalAnnotation	associated	PD	22120873

References

Pubmed ID	Year	Title	Citations
14507979	2003	Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide.	186
16154547	2006	Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study.	109
20124538	2010	Brainstem serotonergic deficiency in sudden infant death syndrome.	105
18982004	2010	Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder.	101
19874574	2009	Genetical genomic determinants of alcohol consumption in rats and humans.	93
20351714	2011	Poor replication of candidate genes for major depressive disorder using genome-wide association data.	92
15758168	2005	A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans.	87
14736842	2004	Reduced serotonin type 1A receptor binding in panic disorder.	86
14744462	2004	Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia.	81
19124686	2009	Effects of HTR1A C(-1019)G on amygdala reactivity and trait anxiety.	67

Citation

Dessen P

HTR1A (5-hydroxytryptamine receptor 1A)

Atlas Genet Cytogenet Oncol Haematol. 2012-06-01

Online version: http://atlasgeneticsoncology.org/gene/52726/htr1a