HTR6 (5-hydroxytryptamine receptor 6)

2014-11-01 Affiliation

Identity

HGNC

HTR6

LOCATION

1p36.13

LOCUSID

3362

ALIAS

5-HT6,5-HT6R

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3362
MIM: 601109
HGNC: 5301
Ensembl: ENSG00000158748

Variants:

dbSNP: 3362
ClinVar: 3362
TCGA: ENSG00000158748
COSMIC: HTR6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000158748	ENST00000289753	P50406

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Serotonergic synapse	KEGG	hsa04726
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Serotonin receptors	REACTOME	R-HSA-390666
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA175	GNAS	Gene	Pathway	associated		19741567
PA444545	Hyperprolactinemia	Disease	VariantAnnotation	associated	PD	19997080
PA447198	Autistic Disorder	Disease	VariantAnnotation	associated	PD	19997080
PA451257	risperidone	Chemical	VariantAnnotation	associated	PD	19997080

References

Pubmed ID	Year	Title	Citations
18583979	2008	Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.	395
19156168	2009	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	46
23027611	2012	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	36
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
20468064	2010	Association study of 182 candidate genes in anorexia nervosa.	30
18855532	2008	Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia.	29
18253134	2009	Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy.	27
16633140	2006	Risperidone-related weight gain: genetic and nongenetic predictors.	26
18079067	2008	Genetic evaluation of the serotonergic system in chronic fatigue syndrome.	23
19193342	2008	Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study.	22

Citation

Dessen P

HTR6 (5-hydroxytryptamine receptor 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64474/htr6