HTRA4 (HtrA serine peptidase 4)

0000-00-00  

Identity

HGNC
HTRA4
LOCATION
8p11.22
LOCUSID
203100
ALIAS
-

Other Information

Locus ID:

NCBI: 203100
MIM: 610700
HGNC: 26909
Ensembl: ENSG00000169495

Variants:

dbSNP: 203100
ClinVar: 203100
TCGA: ENSG00000169495
COSMIC: HTRA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169495ENST00000302495P83105

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
124088152002The HtrA family of proteases: implications for protein composition and cell fate.189
227781382012High-temperature requirement protein A4 (HtrA4) suppresses the fusogenic activity of syncytin-1 and promotes trophoblast invasion.12
229643072012Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia.10
268999962016GATA3 inhibits GCM1 activity and trophoblast cell invasion.8
259460292015Human HtrA4 Expression Is Restricted to the Placenta, Is Significantly Up-Regulated in Early-Onset Preeclampsia, and High Levels of HtrA4 Cause Endothelial Dysfunction.7
250025852014Functional antagonism between high temperature requirement protein A (HtrA) family members regulates trophoblast invasion.3
300159312018Elevated HTRA1 and HTRA4 in severe preeclampsia and their roles in trophoblast functions.3
310367152019Discerning the mechanism of action of HtrA4: a serine protease implicated in the cell death pathway.2
292664442018Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes.0
306389492019Elevated protease HtrA4 in the maternal circulation of preeclampsia may contribute to endothelial barrier disruption by cleaving key junctional protein VE-cadherin.0

Citation

Dessen P

HTRA4 (HtrA serine peptidase 4)

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/gene/52757/htra4