Identity
HGNC
LOCATION
Xp11.22
LOCUSID
ALIAS
ARF-BP1,HECTH9,HSPC272,Ib772,LASU1,MRXST,MULE,URE-B1,UREB1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10075
MIM: 300697
HGNC: 30892
Ensembl: ENSG00000086758
Variants:
dbSNP: 10075
ClinVar: 10075
TCGA: ENSG00000086758
COSMIC: HUWE1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37290064 | 2024 | A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RARα pathway in Chinese individuals. | 0 |
| 37873881 | 2024 | The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis. | 0 |
| 38184713 | 2024 | The E3 ligase HUWE1 increases the sensitivity of CRC to oxaliplatin through TOMM20 degradation. | 2 |
| 37290064 | 2024 | A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RARα pathway in Chinese individuals. | 0 |
| 37873881 | 2024 | The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis. | 0 |
| 38184713 | 2024 | The E3 ligase HUWE1 increases the sensitivity of CRC to oxaliplatin through TOMM20 degradation. | 2 |
| 36961408 | 2023 | HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation. | 2 |
| 37491606 | 2023 | A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant. | 3 |
| 36961408 | 2023 | HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation. | 2 |
| 37491606 | 2023 | A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant. | 3 |
| 35032548 | 2022 | Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation. | 10 |
| 35472332 | 2022 | E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR. | 2 |
| 35848447 | 2022 | The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress glioblastoma progression. | 7 |
| 35921902 | 2022 | TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1. | 1 |
| 35937685 | 2022 | The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases. | 6 |
Citation
Dessen P
HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/42770/huwe1
