HYOU1 (hypoxia up-regulated 1)

2003-06-01  

Identity

HGNC
HYOU1
LOCATION
11q23.3
LOCUSID
10525
ALIAS
GRP-170,Grp170,HSP12A,IMD59,ORP-150,ORP150
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10525
MIM: 601746
HGNC: 16931
Ensembl: ENSG00000149428

Variants:

dbSNP: 10525
ClinVar: 10525
TCGA: ENSG00000149428
COSMIC: HYOU1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149428ENST00000526656J3QL06
ENSG00000149428ENST00000527038J3QQH7
ENSG00000149428ENST00000530467A0A087WW13
ENSG00000149428ENST00000530473E9PJ21
ENSG00000149428ENST00000531968J3KSR2
ENSG00000149428ENST00000532421J3QLE9
ENSG00000149428ENST00000532519K7EQK2
ENSG00000149428ENST00000534233J3KTF1
ENSG00000149428ENST00000543287J3KSR2
ENSG00000149428ENST00000610597A0A087X214
ENSG00000149428ENST00000612687A0A087X054
ENSG00000149428ENST00000614668Q9BST8
ENSG00000149428ENST00000614711A0A087WWI4
ENSG00000149428ENST00000617285Q9Y4L1
ENSG00000149428ENST00000617285A0A384P5T6
ENSG00000149428ENST00000621959A0A087X054
ENSG00000149428ENST00000652093A0A494C039

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging by Class F ReceptorsREACTOMER-HSA-3000484

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
191064122009Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression.58
152405652004ORP150/HSP12A protects renal tubular epithelium from ischemia-induced cell death.27
236456692013The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel.25
256534412015A nucleotide exchange factor promotes endoplasmic reticulum-to-cytosol membrane penetration of the nonenveloped virus simian virus 40.19
249208102014Modulation of Kaposi's sarcoma-associated herpesvirus interleukin-6 function by hypoxia-upregulated protein 1.18
243276592014The large Hsp70 Grp170 binds to unfolded protein substrates in vivo with a regulation distinct from conventional Hsp70s.16
184041582008Oxygen-regulated protein-150 prevents calcium homeostasis deregulation and apoptosis induced by oxidized LDL in vascular cells.15
212968782011Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress.12
258778692015The nucleotide exchange factors Grp170 and Sil1 induce cholera toxin release from BiP to enable retrotranslocation.12

Citation

Dessen P

HYOU1 (hypoxia up-regulated 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40907/hyou1