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IARS1 (isoleucyl-tRNA synthetase 1)

Identity

Alias (NCBI)GRIDHH
IARS
ILERS
ILRS
IRS
PRO0785
HGNC (Hugo) IARS1
HGNC Alias symbILRS
IARS1
HGNC Alias nameisoleucine tRNA ligase 1, cytoplasmic
LocusID (NCBI) 3376
Atlas_Id 64485
Location 9q22.31  [Link to chromosome band 9q22]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)IARS1   5330
Cards
Entrez_Gene (NCBI)IARS1  3376  isoleucyl-tRNA synthetase 1
AliasesGRIDHH; IARS; ILERS; ILRS; 
IRS; PRO0785
GeneCards (Weizmann)IARS1
Ensembl hg19 (Hinxton)ENSG00000196305 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196305 [Gene_View]  ENSG00000196305 [Sequence]  - [Contig_View]  IARS1 [Vega]
ICGC DataPortalENSG00000196305
TCGA cBioPortalIARS1
AceView (NCBI)IARS1
Genatlas (Paris)IARS1
WikiGenes3376
SOURCE (Princeton)IARS1
Genetics Home Reference (NIH)IARS1
Genomic and cartography
GoldenPath hg38 (UCSC)IARS1  -  
GoldenPath hg19 (UCSC)IARS1  -  
GoldenPathIARS1 - [CytoView hg19]  IARS1 - [CytoView hg38]
ImmunoBaseENSG00000196305
genome Data Viewer NCBIIARS1 [Mapview hg19]  
OMIM600709   617093   
Gene and transcription
Genbank (Entrez)AA731323 AB209234 AK057920 AK123909 AK127087
RefSeq transcript (Entrez)NM_001374299 NM_001374300 NM_001374301 NM_002161 NM_013417
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IARS1
Alternative Splicing GalleryENSG00000196305
Gene ExpressionIARS1 [ NCBI-GEO ]   IARS1 [ EBI - ARRAY_EXPRESS ]   IARS1 [ SEEK ]   IARS1 [ MEM ]
Gene Expression Viewer (FireBrowse)IARS1 [ Firebrowse - Broad ]
GenevisibleExpression of IARS1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3376
GTEX Portal (Tissue expression)IARS1
Human Protein AtlasENSG00000196305-IARS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41252   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41252  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41252
Splice isoforms : SwissVarP41252
PhosPhoSitePlusP41252
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ia    Anticodon_Ile_ABEc    Ile-tRNA-ligase    Ile-tRNA-ligase_type2    M/V/L/I-tRNA-synth_anticd-bd    Rossmann-like_a/b/a_fold    tRNAsynth_Ia_anticodon-bd    Val/Leu/Ile-tRNA-synth_edit   
Domain families : Pfam (Sanger)Anticodon_1 (PF08264)    tRNA-synt_1 (PF00133)   
Domain families : Pfam (NCBI)pfam08264    pfam00133   
Conserved Domain (NCBI)IARS1
DMDM Disease mutations3376
Blocks (Seattle)IARS1
SuperfamilyP41252
Human Protein Atlas [tissue]ENSG00000196305-IARS1 [tissue]
Peptide AtlasP41252
HPRD02832
IPIIPI00644127   IPI00978891   IPI00514385   IPI00910980   IPI00982482   IPI00514082   IPI00644198   IPI00644832   
Protein Interaction databases
DIP (DOE-UCLA)P41252
IntAct (EBI)P41252
FunCoupENSG00000196305
BioGRIDIARS1
STRING (EMBL)IARS1
ZODIACIARS1
Ontologies - Pathways
QuickGOP41252
Ontology : AmiGOtRNA binding  osteoblast differentiation  aminoacyl-tRNA editing activity  isoleucine-tRNA ligase activity  isoleucine-tRNA ligase activity  isoleucine-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  isoleucyl-tRNA aminoacylation  isoleucyl-tRNA aminoacylation  membrane  aminoacyl-tRNA synthetase multienzyme complex  GTPase binding  extracellular exosome  aminoacyl-tRNA metabolism involved in translational fidelity  
Ontology : EGO-EBItRNA binding  osteoblast differentiation  aminoacyl-tRNA editing activity  isoleucine-tRNA ligase activity  isoleucine-tRNA ligase activity  isoleucine-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  isoleucyl-tRNA aminoacylation  isoleucyl-tRNA aminoacylation  membrane  aminoacyl-tRNA synthetase multienzyme complex  GTPase binding  extracellular exosome  aminoacyl-tRNA metabolism involved in translational fidelity  
Pathways : KEGGValine, leucine and isoleucine biosynthesis    Aminoacyl-tRNA biosynthesis   
NDEx NetworkIARS1
Atlas of Cancer Signalling NetworkIARS1
Wikipedia pathwaysIARS1
Orthology - Evolution
OrthoDB3376
GeneTree (enSembl)ENSG00000196305
Phylogenetic Trees/Animal Genes : TreeFamIARS1
HOGENOMP41252
Homologs : HomoloGeneIARS1
Homology/Alignments : Family Browser (UCSC)IARS1
Gene fusions - Rearrangements
Fusion : QuiverIARS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIARS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IARS1
dbVarIARS1
ClinVarIARS1
1000_GenomesIARS1 
Exome Variant ServerIARS1
GNOMAD BrowserENSG00000196305
Varsome BrowserIARS1
Genetic variants : HAPMAP3376
Genomic Variants (DGV)IARS1 [DGVbeta]
DECIPHERIARS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIARS1 
Mutations
ICGC Data PortalIARS1 
TCGA Data PortalIARS1 
Broad Tumor PortalIARS1
OASIS PortalIARS1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDIARS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IARS1
DgiDB (Drug Gene Interaction Database)IARS1
DoCM (Curated mutations)IARS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IARS1 (select a term)
intoGenIARS1
Cancer3DIARS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600709    617093   
Orphanet
DisGeNETIARS1
MedgenIARS1
Genetic Testing Registry IARS1
NextProtP41252 [Medical]
TSGene3376
GENETestsIARS1
Target ValidationIARS1
Huge Navigator IARS1 [HugePedia]
snp3D : Map Gene to Disease3376
BioCentury BCIQIARS1
ClinGenIARS1
Clinical trials, drugs, therapy
Protein Interactions : CTD3376
Pharm GKB GenePA29580
Clinical trialIARS1
Miscellaneous
canSAR (ICR)IARS1 (select the gene name)
HarmonizomeIARS1
DataMed IndexIARS1
Probes
Litterature
PubMed122 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIARS1
EVEXIARS1
GoPubMedIARS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Aug 22 19:03:43 CEST 2020

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