ICAM2 (intercellular adhesion molecule 2)

2003-11-01 Affiliation

Identity

HGNC

ICAM2

LOCATION

17q23.3

LOCUSID

3384

ALIAS

CD102

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3384
MIM: 146630
HGNC: 5345
Ensembl: ENSG00000108622

Variants:

dbSNP: 3384
ClinVar: 3384
TCGA: ENSG00000108622
COSMIC: ICAM2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000108622	ENST00000412356	P13598
ENSG00000108622	ENST00000412356	Q6FHE2
ENSG00000108622	ENST00000418105	P13598
ENSG00000108622	ENST00000418105	Q6FHE2
ENSG00000108622	ENST00000449662	P13598
ENSG00000108622	ENST00000449662	Q6FHE2
ENSG00000108622	ENST00000578313	J3QRQ1
ENSG00000108622	ENST00000578379	J3QKR4
ENSG00000108622	ENST00000578892	J3QRT5
ENSG00000108622	ENST00000579687	P13598
ENSG00000108622	ENST00000579687	Q6FHE2
ENSG00000108622	ENST00000579788	P13598
ENSG00000108622	ENST00000579788	Q6FHE2
ENSG00000108622	ENST00000583366	J3QQX6
ENSG00000108622	ENST00000583684	J3KSR9
ENSG00000108622	ENST00000584084	J3QQR8

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933
Innate Immune System	REACTOME	R-HSA-168249
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CD209 (DC-SIGN) signaling	REACTOME	R-HSA-5621575
Extracellular matrix organization	REACTOME	R-HSA-1474244
Integrin cell surface interactions	REACTOME	R-HSA-216083

References

Pubmed ID	Year	Title	Citations
15548573	2005	Targeting leukocyte integrins in human diseases.	52
20955708	2011	CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis.	49
12097408	2002	Intercellular adhesion molecule (ICAM)-1, but not ICAM-2, activates RhoA and stimulates c-fos and rhoA transcription in endothelial cells.	38
17609265	2007	Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells.	31
15545280	2005	Contribution of N-linked glycans to the conformation and function of intercellular adhesion molecules (ICAMs).	29
23591197	2013	MicroRNA-125b regulates proliferation and radioresistance of oral squamous cell carcinoma.	29
16857989	2006	alpha-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation.	28
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
18155766	2008	DC-SIGN mediates adhesion and rolling of dendritic cells on primary human umbilical vein endothelial cells through LewisY antigen expressed on ICAM-2.	26
14970226	2004	DC-SIGN binds to HIV-1 glycoprotein 120 in a distinct but overlapping fashion compared with ICAM-2 and ICAM-3.	25

Citation

Dessen P

ICAM2 (intercellular adhesion molecule 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40910/icam2