ICAM4 (intercellular adhesion molecule 4 (Landsteiner-Wiener blood group))

2007-04-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
CD242,LW

Other Information

Locus ID:

NCBI: 3386
MIM: 614088
HGNC: 5347
Ensembl: ENSG00000105371

Variants:

dbSNP: 3386
ClinVar: 3386
TCGA: ENSG00000105371
COSMIC: ICAM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105371ENST00000340992Q14773
ENSG00000105371ENST00000340992U5U6P8
ENSG00000105371ENST00000380770Q14773
ENSG00000105371ENST00000393717Q14773

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
176094302007Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo.47
153085662004Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions.42
158476542005A flexible array format for large-scale, rapid blood group DNA typing.30
203313782010Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.29
221478982012Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium.27
204160772010Identification of type 2 diabetes-associated combination of SNPs using support vector machine.26
124777172003Red cell ICAM-4 is a novel ligand for platelet-activated alpha IIbbeta 3 integrin.21
169851752007Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4.19
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19

Citation

Dessen P

ICAM4 (intercellular adhesion molecule 4 (Landsteiner-Wiener blood group))

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46763/icam4