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ICE2 (interactor of little elongation complex ELL subunit 2)

Identity

Alias (NCBI)BRCC1
NARG2
HGNC (Hugo) ICE2
HGNC Alias symbFLJ11896
BRCC1
HGNC Alias namebreast cancer cell 1
HGNC Previous nameNARG2
HGNC Previous nameNMDA receptor regulated 2
LocusID (NCBI) 79664
Atlas_Id 64492
Location 15q22.2  [Link to chromosome band 15q22]
Location_base_pair Starts at 60419609 and ends at 60479160 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANXA2 (15q22.2) / ICE2 (15q22.2)ICE2 (15q22.2) / ALDH1A2 (15q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(15;15)(q21;q22) ICE2/ALDH1A2

External links

Nomenclature
HGNC (Hugo)ICE2   29885
Cards
Entrez_Gene (NCBI)ICE2    interactor of little elongation complex ELL subunit 2
AliasesBRCC1; NARG2
GeneCards (Weizmann)ICE2
Ensembl hg19 (Hinxton)ENSG00000128915 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128915 [Gene_View]  ENSG00000128915 [Sequence]  chr15:60419609-60479160 [Contig_View]  ICE2 [Vega]
ICGC DataPortalENSG00000128915
TCGA cBioPortalICE2
AceView (NCBI)ICE2
Genatlas (Paris)ICE2
SOURCE (Princeton)ICE2
Genetics Home Reference (NIH)ICE2
Genomic and cartography
GoldenPath hg38 (UCSC)ICE2  -     chr15:60419609-60479160 -  15q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ICE2  -     15q22.2   [Description]    (hg19-Feb_2009)
GoldenPathICE2 - 15q22.2 [CytoView hg19]  ICE2 - 15q22.2 [CytoView hg38]
ImmunoBaseENSG00000128915
genome Data Viewer NCBIICE2 [Mapview hg19]  
OMIM610835   
Gene and transcription
Genbank (Entrez)AF502591 AK021958 AK055752 AK095389 AK127892
RefSeq transcript (Entrez)NM_001018089 NM_001276385 NM_024611
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ICE2
Alternative Splicing GalleryENSG00000128915
Gene ExpressionICE2 [ NCBI-GEO ]   ICE2 [ EBI - ARRAY_EXPRESS ]   ICE2 [ SEEK ]   ICE2 [ MEM ]
Gene Expression Viewer (FireBrowse)ICE2 [ Firebrowse - Broad ]
GenevisibleExpression of ICE2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79664
GTEX Portal (Tissue expression)ICE2
Human Protein AtlasENSG00000128915-ICE2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ659A1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ659A1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ659A1
Splice isoforms : SwissVarQ659A1
PhosPhoSitePlusQ659A1
Domains : Interpro (EBI)ICE2_C   
Domain families : Pfam (Sanger)NARG2_C (PF10505)   
Domain families : Pfam (NCBI)pfam10505   
Conserved Domain (NCBI)ICE2
Blocks (Seattle)ICE2
SuperfamilyQ659A1
Human Protein Atlas [tissue]ENSG00000128915-ICE2 [tissue]
Peptide AtlasQ659A1
HPRD17628
IPIIPI00470407   IPI00604683   IPI01022154   
Protein Interaction databases
DIP (DOE-UCLA)Q659A1
IntAct (EBI)Q659A1
BioGRIDICE2
STRING (EMBL)ICE2
ZODIACICE2
Ontologies - Pathways
QuickGOQ659A1
Ontology : AmiGOprotein binding  nucleoplasm  nucleoplasm  cytosol  transcription elongation factor complex  transcription elongation factor complex  Cajal body  nuclear body  transcriptionally active chromatin  histone locus body  snRNA transcription by RNA polymerase II  snRNA transcription by RNA polymerase II  snRNA transcription by RNA polymerase II  snRNA transcription by RNA polymerase III  snRNA transcription by RNA polymerase III  positive regulation of transcription by RNA polymerase III  positive regulation of transcription by RNA polymerase III  
Ontology : EGO-EBIprotein binding  nucleoplasm  nucleoplasm  cytosol  transcription elongation factor complex  transcription elongation factor complex  Cajal body  nuclear body  transcriptionally active chromatin  histone locus body  snRNA transcription by RNA polymerase II  snRNA transcription by RNA polymerase II  snRNA transcription by RNA polymerase II  snRNA transcription by RNA polymerase III  snRNA transcription by RNA polymerase III  positive regulation of transcription by RNA polymerase III  positive regulation of transcription by RNA polymerase III  
NDEx NetworkICE2
Atlas of Cancer Signalling NetworkICE2
Wikipedia pathwaysICE2
Orthology - Evolution
OrthoDB79664
GeneTree (enSembl)ENSG00000128915
Phylogenetic Trees/Animal Genes : TreeFamICE2
HOGENOMQ659A1
Homologs : HomoloGeneICE2
Homology/Alignments : Family Browser (UCSC)ICE2
Gene fusions - Rearrangements
Fusion : QuiverICE2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerICE2 [hg38]
dbVarICE2
ClinVarICE2
MonarchICE2
1000_GenomesICE2 
Exome Variant ServerICE2
GNOMAD BrowserENSG00000128915
Varsome BrowserICE2
Genomic Variants (DGV)ICE2 [DGVbeta]
DECIPHERICE2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisICE2 
Mutations
ICGC Data PortalICE2 
TCGA Data PortalICE2 
Broad Tumor PortalICE2
OASIS PortalICE2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICICE2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DICE2
Mutations and Diseases : HGMDICE2
BioMutasearch ICE2
DgiDB (Drug Gene Interaction Database)ICE2
DoCM (Curated mutations)ICE2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ICE2 (select a term)
intoGenICE2
Cancer3DICE2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610835   
Orphanet
DisGeNETICE2
MedgenICE2
Genetic Testing Registry ICE2
NextProtQ659A1 [Medical]
GENETestsICE2
Target ValidationICE2
Huge Navigator ICE2 [HugePedia]
ClinGenICE2
Clinical trials, drugs, therapy
MyCancerGenomeICE2
Protein Interactions : CTD
Pharm GKB GenePA134960292
Clinical trialICE2
Miscellaneous
canSAR (ICR)ICE2 (select the gene name)
HarmonizomeICE2
DataMed IndexICE2
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineICE2
EVEXICE2
GoPubMedICE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 16:57:30 CET 2020
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