Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ICOSLG (inducible T cell costimulator ligand)

Identity

Alias_namesICOSL
inducible T-cell costimulator ligand
Alias_symbol (synonym)KIAA0653
GL50
B7-H2
B7RP-1
B7H2
B7RP1
ICOS-L
CD275
B7h
Other aliasLICOS
HGNC (Hugo) ICOSLG
LocusID (NCBI) 23308
Atlas_Id 46042
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 44226827 and ends at 44241004 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LOC100507412 (-) / ICOSLG (21q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ICOSLG   17087
Cards
Entrez_Gene (NCBI)ICOSLG  23308  inducible T cell costimulator ligand
AliasesB7-H2; B7H2; B7RP-1; B7RP1; 
B7h; CD275; GL50; ICOS-L; ICOSL; LICOS
GeneCards (Weizmann)ICOSLG
Ensembl hg19 (Hinxton)ENSG00000160223 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160223 [Gene_View]  ENSG00000160223 [Sequence]  chr21:44226827-44241004 [Contig_View]  ICOSLG [Vega]
ICGC DataPortalENSG00000160223
TCGA cBioPortalICOSLG
AceView (NCBI)ICOSLG
Genatlas (Paris)ICOSLG
WikiGenes23308
SOURCE (Princeton)ICOSLG
Genetics Home Reference (NIH)ICOSLG
Genomic and cartography
GoldenPath hg38 (UCSC)ICOSLG  -     chr21:44226827-44241004 -  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ICOSLG  -     21q22.3   [Description]    (hg19-Feb_2009)
GoldenPathICOSLG - 21q22.3 [CytoView hg19]  ICOSLG - 21q22.3 [CytoView hg38]
ImmunoBaseENSG00000160223
Mapping of homologs : NCBIICOSLG [Mapview hg19]  ICOSLG [Mapview hg38]
OMIM605717   
Gene and transcription
Genbank (Entrez)AA781960 AB014553 AF199028 AF216749 AF289028
RefSeq transcript (Entrez)NM_001283050 NM_001283051 NM_001283052 NM_001365759 NM_015259
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ICOSLG
Cluster EST : UnigeneHs.14155 [ NCBI ]
CGAP (NCI)Hs.14155
Alternative Splicing GalleryENSG00000160223
Gene ExpressionICOSLG [ NCBI-GEO ]   ICOSLG [ EBI - ARRAY_EXPRESS ]   ICOSLG [ SEEK ]   ICOSLG [ MEM ]
Gene Expression Viewer (FireBrowse)ICOSLG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23308
GTEX Portal (Tissue expression)ICOSLG
Human Protein AtlasENSG00000160223-ICOSLG [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75144   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75144  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75144
Splice isoforms : SwissVarO75144
PhosPhoSitePlusO75144
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD80_C2-set    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_V-set   
Domain families : Pfam (Sanger)C2-set_2 (PF08205)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam08205    pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)ICOSLG
DMDM Disease mutations23308
Blocks (Seattle)ICOSLG
SuperfamilyO75144
Human Protein Atlas [tissue]ENSG00000160223-ICOSLG [tissue]
Peptide AtlasO75144
HPRD05757
IPIIPI00219131   IPI00414888   IPI00796189   IPI00790218   
Protein Interaction databases
DIP (DOE-UCLA)O75144
IntAct (EBI)O75144
FunCoupENSG00000160223
BioGRIDICOSLG
STRING (EMBL)ICOSLG
ZODIACICOSLG
Ontologies - Pathways
QuickGOO75144
Ontology : AmiGOadaptive immune response  signaling receptor binding  signaling receptor binding  protein binding  plasma membrane  plasma membrane  defense response  hyperosmotic response  signal transduction  external side of plasma membrane  integral component of membrane  T cell costimulation  cytoplasmic ribonucleoprotein granule  positive regulation of activated T cell proliferation  T cell activation  B cell activation  identical protein binding  regulation of immune response  T cell receptor signaling pathway  extracellular exosome  
Ontology : EGO-EBIadaptive immune response  signaling receptor binding  signaling receptor binding  protein binding  plasma membrane  plasma membrane  defense response  hyperosmotic response  signal transduction  external side of plasma membrane  integral component of membrane  T cell costimulation  cytoplasmic ribonucleoprotein granule  positive regulation of activated T cell proliferation  T cell activation  B cell activation  identical protein binding  regulation of immune response  T cell receptor signaling pathway  extracellular exosome  
Pathways : KEGGCell adhesion molecules (CAMs)    Intestinal immune network for IgA production   
NDEx NetworkICOSLG
Atlas of Cancer Signalling NetworkICOSLG
Wikipedia pathwaysICOSLG
Orthology - Evolution
OrthoDB23308
GeneTree (enSembl)ENSG00000160223
Phylogenetic Trees/Animal Genes : TreeFamICOSLG
HOGENOMO75144
Homologs : HomoloGeneICOSLG
Homology/Alignments : Family Browser (UCSC)ICOSLG
Gene fusions - Rearrangements
Fusion : QuiverICOSLG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerICOSLG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ICOSLG
dbVarICOSLG
ClinVarICOSLG
1000_GenomesICOSLG 
Exome Variant ServerICOSLG
ExAC (Exome Aggregation Consortium)ENSG00000160223
GNOMAD BrowserENSG00000160223
Varsome BrowserICOSLG
Genetic variants : HAPMAP23308
Genomic Variants (DGV)ICOSLG [DGVbeta]
DECIPHERICOSLG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisICOSLG 
Mutations
ICGC Data PortalICOSLG 
TCGA Data PortalICOSLG 
Broad Tumor PortalICOSLG
OASIS PortalICOSLG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICICOSLG  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DICOSLG
Mutations and Diseases : HGMDICOSLG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ICOSLG
DgiDB (Drug Gene Interaction Database)ICOSLG
DoCM (Curated mutations)ICOSLG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ICOSLG (select a term)
intoGenICOSLG
Cancer3DICOSLG(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605717   
Orphanet
DisGeNETICOSLG
MedgenICOSLG
Genetic Testing Registry ICOSLG
NextProtO75144 [Medical]
TSGene23308
GENETestsICOSLG
Target ValidationICOSLG
Huge Navigator ICOSLG [HugePedia]
snp3D : Map Gene to Disease23308
BioCentury BCIQICOSLG
ClinGenICOSLG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23308
Chemical/Pharm GKB GenePA134977297
Clinical trialICOSLG
Miscellaneous
canSAR (ICR)ICOSLG (select the gene name)
DataMed IndexICOSLG
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineICOSLG
EVEXICOSLG
GoPubMedICOSLG
iHOPICOSLG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Aug 26 18:12:08 CEST 2019
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