Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IDH3A (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha)

Identity

Alias_namesisocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase (NAD(+)) 3 alpha
Other alias-
HGNC (Hugo) IDH3A
LocusID (NCBI) 3419
Atlas_Id 55555
Location 15q25.1  [Link to chromosome band 15q25]
Location_base_pair Starts at 78149377 and ends at 78170542 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IDH3A (15q25.1) / IDH3A (15q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  ACSBG1/IDH3A (15q25)

External links

Nomenclature
HGNC (Hugo)IDH3A   5384
Cards
Entrez_Gene (NCBI)IDH3A  3419  isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
Aliases
GeneCards (Weizmann)IDH3A
Ensembl hg19 (Hinxton)ENSG00000166411 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166411 [Gene_View]  ENSG00000166411 [Sequence]  chr15:78149377-78170542 [Contig_View]  IDH3A [Vega]
ICGC DataPortalENSG00000166411
TCGA cBioPortalIDH3A
AceView (NCBI)IDH3A
Genatlas (Paris)IDH3A
WikiGenes3419
SOURCE (Princeton)IDH3A
Genetics Home Reference (NIH)IDH3A
Genomic and cartography
GoldenPath hg38 (UCSC)IDH3A  -     chr15:78149377-78170542 +  15q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IDH3A  -     15q25.1   [Description]    (hg19-Feb_2009)
GoldenPathIDH3A - 15q25.1 [CytoView hg19]  IDH3A - 15q25.1 [CytoView hg38]
ImmunoBaseENSG00000166411
Mapping of homologs : NCBIIDH3A [Mapview hg19]  IDH3A [Mapview hg38]
OMIM601149   
Gene and transcription
Genbank (Entrez)AK093531 AK096721 AK222973 AK296002 AK299970
RefSeq transcript (Entrez)NM_005530
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IDH3A
Cluster EST : UnigeneHs.591110 [ NCBI ]
CGAP (NCI)Hs.591110
Alternative Splicing GalleryENSG00000166411
Gene ExpressionIDH3A [ NCBI-GEO ]   IDH3A [ EBI - ARRAY_EXPRESS ]   IDH3A [ SEEK ]   IDH3A [ MEM ]
Gene Expression Viewer (FireBrowse)IDH3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3419
GTEX Portal (Tissue expression)IDH3A
Human Protein AtlasENSG00000166411-IDH3A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50213   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50213  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50213
Splice isoforms : SwissVarP50213
Catalytic activity : Enzyme1.1.1.41 [ Enzyme-Expasy ]   1.1.1.411.1.1.41 [ IntEnz-EBI ]   1.1.1.41 [ BRENDA ]   1.1.1.41 [ KEGG ]   
PhosPhoSitePlusP50213
Domaine pattern : Prosite (Expaxy)IDH_IMDH (PS00470)   
Domains : Interpro (EBI)IsoCit/isopropylmalate_DH_CS    Isocitrate_DH_NAD    IsoPropMal-DH-like_dom   
Domain families : Pfam (Sanger)Iso_dh (PF00180)   
Domain families : Pfam (NCBI)pfam00180   
Domain families : Smart (EMBL)Iso_dh (SM01329)  
Conserved Domain (NCBI)IDH3A
DMDM Disease mutations3419
Blocks (Seattle)IDH3A
PDB (RSDB)5GRE    5GRF    5GRH    5GRI    5GRL    5YVT   
PDB Europe5GRE    5GRF    5GRH    5GRI    5GRL    5YVT   
PDB (PDBSum)5GRE    5GRF    5GRH    5GRI    5GRL    5YVT   
PDB (IMB)5GRE    5GRF    5GRH    5GRI    5GRL    5YVT   
Structural Biology KnowledgeBase5GRE    5GRF    5GRH    5GRI    5GRL    5YVT   
SCOP (Structural Classification of Proteins)5GRE    5GRF    5GRH    5GRI    5GRL    5YVT   
CATH (Classification of proteins structures)5GRE    5GRF    5GRH    5GRI    5GRL    5YVT   
SuperfamilyP50213
Human Protein Atlas [tissue]ENSG00000166411-IDH3A [tissue]
Peptide AtlasP50213
HPRD03094
IPIIPI00030702   IPI00792971   IPI00909577   IPI00921820   IPI00470851   
Protein Interaction databases
DIP (DOE-UCLA)P50213
IntAct (EBI)P50213
FunCoupENSG00000166411
BioGRIDIDH3A
STRING (EMBL)IDH3A
ZODIACIDH3A
Ontologies - Pathways
QuickGOP50213
Ontology : AmiGOmagnesium ion binding  isocitrate dehydrogenase (NAD+) activity  isocitrate dehydrogenase (NAD+) activity  nucleus  mitochondrion  mitochondrion  mitochondrial matrix  carbohydrate metabolic process  tricarboxylic acid cycle  tricarboxylic acid cycle  isocitrate metabolic process  NAD binding  
Ontology : EGO-EBImagnesium ion binding  isocitrate dehydrogenase (NAD+) activity  isocitrate dehydrogenase (NAD+) activity  nucleus  mitochondrion  mitochondrion  mitochondrial matrix  carbohydrate metabolic process  tricarboxylic acid cycle  tricarboxylic acid cycle  isocitrate metabolic process  NAD binding  
Pathways : KEGGCitrate cycle (TCA cycle)   
NDEx NetworkIDH3A
Atlas of Cancer Signalling NetworkIDH3A
Wikipedia pathwaysIDH3A
Orthology - Evolution
OrthoDB3419
GeneTree (enSembl)ENSG00000166411
Phylogenetic Trees/Animal Genes : TreeFamIDH3A
HOGENOMP50213
Homologs : HomoloGeneIDH3A
Homology/Alignments : Family Browser (UCSC)IDH3A
Gene fusions - Rearrangements
Fusion : QuiverIDH3A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIDH3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IDH3A
dbVarIDH3A
ClinVarIDH3A
1000_GenomesIDH3A 
Exome Variant ServerIDH3A
ExAC (Exome Aggregation Consortium)ENSG00000166411
GNOMAD BrowserENSG00000166411
Varsome BrowserIDH3A
Genetic variants : HAPMAP3419
Genomic Variants (DGV)IDH3A [DGVbeta]
DECIPHERIDH3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIDH3A 
Mutations
ICGC Data PortalIDH3A 
TCGA Data PortalIDH3A 
Broad Tumor PortalIDH3A
OASIS PortalIDH3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIDH3A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIDH3A
Mutations and Diseases : HGMDIDH3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch IDH3A
DgiDB (Drug Gene Interaction Database)IDH3A
DoCM (Curated mutations)IDH3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IDH3A (select a term)
intoGenIDH3A
Cancer3DIDH3A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601149   
Orphanet
DisGeNETIDH3A
MedgenIDH3A
Genetic Testing Registry IDH3A
NextProtP50213 [Medical]
TSGene3419
GENETestsIDH3A
Target ValidationIDH3A
Huge Navigator IDH3A [HugePedia]
snp3D : Map Gene to Disease3419
BioCentury BCIQIDH3A
ClinGenIDH3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3419
Chemical/Pharm GKB GenePA29632
Clinical trialIDH3A
Miscellaneous
canSAR (ICR)IDH3A (select the gene name)
DataMed IndexIDH3A
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIDH3A
EVEXIDH3A
GoPubMedIDH3A
iHOPIDH3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:47:44 CET 2019
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