Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IDH3B (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta)

Identity

Alias_namesisocitrate dehydrogenase 3 (NAD+) beta
isocitrate dehydrogenase (NAD(+)) 3 beta
Alias_symbol (synonym)RP46
Other alias
HGNC (Hugo) IDH3B
LocusID (NCBI) 3420
Atlas_Id 53966
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 2658390 and ends at 2664223 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IDH3B (20p13) / IDH3B (20p13)IDH3B (20p13) / JUP (17q21.2)MYT1L (2p25.3) / IDH3B (20p13)
PSAP (10q22.1) / IDH3B (20p13)UBAC2 (13q32.3) / IDH3B (20p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IDH3B   5385
Cards
Entrez_Gene (NCBI)IDH3B  3420  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
AliasesRP46
GeneCards (Weizmann)IDH3B
Ensembl hg19 (Hinxton)ENSG00000101365 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101365 [Gene_View]  ENSG00000101365 [Sequence]  chr20:2658390-2664223 [Contig_View]  IDH3B [Vega]
ICGC DataPortalENSG00000101365
TCGA cBioPortalIDH3B
AceView (NCBI)IDH3B
Genatlas (Paris)IDH3B
WikiGenes3420
SOURCE (Princeton)IDH3B
Genetics Home Reference (NIH)IDH3B
Genomic and cartography
GoldenPath hg38 (UCSC)IDH3B  -     chr20:2658390-2664223 -  20p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IDH3B  -     20p13   [Description]    (hg19-Feb_2009)
GoldenPathIDH3B - 20p13 [CytoView hg19]  IDH3B - 20p13 [CytoView hg38]
ImmunoBaseENSG00000101365
Mapping of homologs : NCBIIDH3B [Mapview hg19]  IDH3B [Mapview hg38]
OMIM604526   612572   
Gene and transcription
Genbank (Entrez)AK001905 AK300485 AK309488 AK315641 AL050094
RefSeq transcript (Entrez)NM_001258384 NM_001330763 NM_006899 NM_174855 NM_174856
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IDH3B
Cluster EST : UnigeneHs.436405 [ NCBI ]
CGAP (NCI)Hs.436405
Alternative Splicing GalleryENSG00000101365
Gene ExpressionIDH3B [ NCBI-GEO ]   IDH3B [ EBI - ARRAY_EXPRESS ]   IDH3B [ SEEK ]   IDH3B [ MEM ]
Gene Expression Viewer (FireBrowse)IDH3B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3420
GTEX Portal (Tissue expression)IDH3B
Human Protein AtlasENSG00000101365-IDH3B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43837   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43837  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43837
Splice isoforms : SwissVarO43837
Catalytic activity : Enzyme1.1.1.41 [ Enzyme-Expasy ]   1.1.1.411.1.1.41 [ IntEnz-EBI ]   1.1.1.41 [ BRENDA ]   1.1.1.41 [ KEGG ]   
PhosPhoSitePlusO43837
Domaine pattern : Prosite (Expaxy)IDH_IMDH (PS00470)   
Domains : Interpro (EBI)IsoCit/isopropylmalate_DH_CS    Isocitrate_DH_NAD    IsoPropMal-DH-like_dom   
Domain families : Pfam (Sanger)Iso_dh (PF00180)   
Domain families : Pfam (NCBI)pfam00180   
Domain families : Smart (EMBL)Iso_dh (SM01329)  
Conserved Domain (NCBI)IDH3B
DMDM Disease mutations3420
Blocks (Seattle)IDH3B
SuperfamilyO43837
Human Protein Atlas [tissue]ENSG00000101365-IDH3B [tissue]
Peptide AtlasO43837
HPRD05163
IPIIPI00304419   IPI00871304   IPI00844566   IPI00383639   IPI00304417   
Protein Interaction databases
DIP (DOE-UCLA)O43837
IntAct (EBI)O43837
FunCoupENSG00000101365
BioGRIDIDH3B
STRING (EMBL)IDH3B
ZODIACIDH3B
Ontologies - Pathways
QuickGOO43837
Ontology : AmiGOmagnesium ion binding  isocitrate dehydrogenase (NAD+) activity  nucleus  mitochondrion  mitochondrion  mitochondrial matrix  tricarboxylic acid cycle  tricarboxylic acid cycle  isocitrate metabolic process  electron transfer activity  electron transport chain  NAD binding  
Ontology : EGO-EBImagnesium ion binding  isocitrate dehydrogenase (NAD+) activity  nucleus  mitochondrion  mitochondrion  mitochondrial matrix  tricarboxylic acid cycle  tricarboxylic acid cycle  isocitrate metabolic process  electron transfer activity  electron transport chain  NAD binding  
Pathways : KEGGCitrate cycle (TCA cycle)   
NDEx NetworkIDH3B
Atlas of Cancer Signalling NetworkIDH3B
Wikipedia pathwaysIDH3B
Orthology - Evolution
OrthoDB3420
GeneTree (enSembl)ENSG00000101365
Phylogenetic Trees/Animal Genes : TreeFamIDH3B
HOGENOMO43837
Homologs : HomoloGeneIDH3B
Homology/Alignments : Family Browser (UCSC)IDH3B
Gene fusions - Rearrangements
Fusion : QuiverIDH3B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIDH3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IDH3B
dbVarIDH3B
ClinVarIDH3B
1000_GenomesIDH3B 
Exome Variant ServerIDH3B
ExAC (Exome Aggregation Consortium)ENSG00000101365
GNOMAD BrowserENSG00000101365
Varsome BrowserIDH3B
Genetic variants : HAPMAP3420
Genomic Variants (DGV)IDH3B [DGVbeta]
DECIPHERIDH3B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIDH3B 
Mutations
ICGC Data PortalIDH3B 
TCGA Data PortalIDH3B 
Broad Tumor PortalIDH3B
OASIS PortalIDH3B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIDH3B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIDH3B
Mutations and Diseases : HGMDIDH3B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch IDH3B
DgiDB (Drug Gene Interaction Database)IDH3B
DoCM (Curated mutations)IDH3B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IDH3B (select a term)
intoGenIDH3B
Cancer3DIDH3B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604526    612572   
Orphanet659   
DisGeNETIDH3B
MedgenIDH3B
Genetic Testing Registry IDH3B
NextProtO43837 [Medical]
TSGene3420
GENETestsIDH3B
Target ValidationIDH3B
Huge Navigator IDH3B [HugePedia]
snp3D : Map Gene to Disease3420
BioCentury BCIQIDH3B
ClinGenIDH3B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3420
Chemical/Pharm GKB GenePA29633
Clinical trialIDH3B
Miscellaneous
canSAR (ICR)IDH3B (select the gene name)
DataMed IndexIDH3B
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIDH3B
EVEXIDH3B
GoPubMedIDH3B
iHOPIDH3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:47:44 CET 2019
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