IFITM1 (interferon induced transmembrane protein 1)

2007-02-01  

Identity

HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
9-27,CD225,DSPA2a,IFI17,LEU13
FUSION GENES

Other Information

Locus ID:

NCBI: 8519
MIM: 604456
HGNC: 5412
Ensembl: ENSG00000185885

Variants:

dbSNP: 8519
ClinVar: 8519
TCGA: ENSG00000185885
COSMIC: IFITM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185885ENST00000328221P13164
ENSG00000185885ENST00000408968P13164
ENSG00000185885ENST00000528780P13164

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
B cell receptor signaling pathwayKEGGko04662
B cell receptor signaling pathwayKEGGhsa04662
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200643712009The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.575
212535752011Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.236
211778062011The IFITM proteins inhibit HIV-1 infection.187
229962922013IFITM1 is a tight junction protein that inhibits hepatitis C virus entry.80
272685052016The IFITMs Inhibit Zika Virus Replication.80
219766472011ISG56 and IFITM1 proteins inhibit hepatitis C virus replication.76
237207212013IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus.68
254648292014IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.65
227872042012Hepatitis C virus infection modulates expression of interferon stimulatory gene IFITM1 by upregulating miR-130A.53
254220702014IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity.49

Citation

Dessen P

IFITM1 (interferon induced transmembrane protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43707/ifitm1