IFITM3 (interferon induced transmembrane protein 3)

2008-09-01  

Identity

HGNC
IFITM3
LOCATION
11p15.5
LOCUSID
10410
ALIAS
1-8U,DSPA2b,IP15

Other Information

Locus ID:

NCBI: 10410
MIM: 605579
HGNC: 5414
Ensembl: ENSG00000142089

Variants:

dbSNP: 10410
ClinVar: 10410
TCGA: ENSG00000142089
COSMIC: IFITM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142089ENST00000399808Q01628
ENSG00000142089ENST00000526811E9PS44
ENSG00000142089ENST00000531688R4GNG9
ENSG00000142089ENST00000602735E9PS44

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
224466282012IFITM3 restricts the morbidity and mortality associated with influenza.313
211778062011The IFITM proteins inhibit HIV-1 infection.187
205348632010Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.175
236011072013The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry.136
233610092013Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals.118
246996742014IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion.117
243671042014Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection.114
225117832012S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus.90
236584542013The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication.80
272685052016The IFITMs Inhibit Zika Virus Replication.80

Citation

Dessen P

IFITM3 (interferon induced transmembrane protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50373/ifitm3