IFNAR2 (interferon alpha and beta receptor subunit 2)

2003-11-01  

Identity

HGNC
IFNAR2
LOCATION
21q22.11
LOCUSID
3455
ALIAS
IFN-R,IFN-alpha-REC,IFNABR,IFNARB,IMD45
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3455
MIM: 602376
HGNC: 5433
Ensembl: ENSG00000249624

Variants:

dbSNP: 3455
ClinVar: 3455
TCGA: ENSG00000249624
COSMIC: IFNAR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000249624ENST00000432231H7C3V1
ENSG00000249624ENST00000433395H0Y3Z8

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Toll-like receptor signaling pathwayKEGGko04620
Jak-STAT signaling pathwayKEGGko04630
Natural killer cell mediated cytotoxicityKEGGko04650
Cytokine-cytokine receptor interactionKEGGhsa04060
Toll-like receptor signaling pathwayKEGGhsa04620
Jak-STAT signaling pathwayKEGGhsa04630
Natural killer cell mediated cytotoxicityKEGGhsa04650
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Regulation of IFNA signalingREACTOMER-HSA-912694

References

Pubmed IDYearTitleCitations
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
188017362008The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities.49
216902952011Stochastic receptor expression determines cell fate upon interferon treatment.48
194016922009Activation of Wnt/beta-catenin signalling pathway induces chemoresistance to interferon-alpha/5-fluorouracil combination therapy for hepatocellular carcinoma.39
161062662005Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression.36
208116262010Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.34
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
187153392008Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population.31
260087452015Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling.30

Citation

Dessen P

IFNAR2 (interferon alpha and beta receptor subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40923/ifnar2