IFNL2 (interferon lambda 2)

2007-02-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
IFNL2a,IFNL3a,IL-28A,IL28A

Other Information

Locus ID:

NCBI: 282616
MIM: 607401
HGNC: 18364
Ensembl: ENSG00000183709

Variants:

dbSNP: 282616
ClinVar: 282616
TCGA: ENSG00000183709
COSMIC: IFNL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183709ENST00000331982Q8IZJ0

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124832102003IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.581
124691192003IL-28, IL-29 and their class II cytokine receptor IL-28R.481
197980762009Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines.83
228912842012Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells.63
158507932005SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29.31
243854352014Transcriptional regulation of IFN-λ genes in hepatitis C virus-infected hepatocytes via IRF-3·IRF-7·NF-κB complex.21
263539652015Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation.21
228257572012Role of the p38 MAPK signaling pathway in mediating interleukin-28A-induced migration of UMUC-3 cells.18
229625762012Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; the roles of IL-5, IL-20, and IL-28A.15
158995852005Biological activity of interleukins-28 and -29: comparison with type I interferons.0

Citation

Dessen P

IFNL2 (interferon lambda 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45886/ifnl2