IFNL3 (interferon lambda 3)

2009-09-01 Affiliation

Identity

HGNC

IFNL3

LOCATION

19q13.2

LOCUSID

282617

ALIAS

IFN-lambda-3,IFN-lambda-4,IL-28B,IL-28C,IL28B,IL28C

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 282617
MIM: 607402
HGNC: 18365
Ensembl: ENSG00000197110

Variants:

dbSNP: 282617
ClinVar: 282617
TCGA: ENSG00000197110
COSMIC: IFNL3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000197110	ENST00000413851	Q8IZI9
ENSG00000197110	ENST00000613087	A0A0C4DGW8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Jak-STAT signaling pathway	KEGG	ko04630
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Jak-STAT signaling pathway	KEGG	hsa04630
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164749390	peginterferon alfa-2a	Chemical	ClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	associated	PD	19684573, 19749757, 19749758, 20060832, 20399780, 20434452, 20578254, 20621700, 20648473, 20728570, 20804372, 20964522, 21068134, 21112657, 21112660, 21145807, 21246582, 21254157, 21346780, 21360545, 21374656, 21384511, 21390311, 21447862, 21466653, 21503910, 21537116, 21572301, 21606533, 21726252, 21739446, 21745312, 21907615, 21911885, 21951981, 21987611, 21993426, 22301466, 22328925, 22345656, 22438096, 22863269, 23142377, 23281610, 23321318, 23383658, 23490377, 23730840, 24072198, 24096968, 24102823, 24117654, 24308755, 24355007, 24362944, 24602923, 24768758, 24907224, 24929144, 25080450, 25287681, 25534433, 25769643, 25918016, 25958342, 26003758, 26032235, 26186989, 26284539, 26825765, 26902034, 27498543, 27514956, 27714501, 27833958, 28072888, 28261910, 28453395, 28703131, 28739427, 29369421, 30016335, 30450628, 31201901
PA164784024	peginterferon alfa-2b	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	associated	PD	19684573, 19749757, 19749758, 20060832, 20399780, 20434452, 20578254, 20621700, 20648473, 20728570, 20804372, 20964522, 21068134, 21112657, 21112660, 21145807, 21246582, 21254157, 21346780, 21360545, 21374656, 21384511, 21390311, 21447862, 21466653, 21503910, 21537116, 21572301, 21606533, 21726252, 21739446, 21745312, 21907615, 21911885, 21951981, 21987611, 21993426, 22301466, 22328925, 22345656, 22438096, 22626609, 22863269, 23142377, 23281610, 23321318, 23383658, 23490377, 23730840, 24072198, 24096968, 24102823, 24117654, 24308755, 24355007, 24362944, 24602923, 24768758, 24907224, 24929144, 25080450, 25287681, 25534433, 25769643, 25918016, 25958342, 26003758, 26032235, 26186989, 26284539, 26825765, 26902034, 27498543, 27514956, 27714501, 27833958, 28072888, 28261910, 28703131, 28739427, 29369421, 30450628
PA165948902	boceprevir	Chemical	ClinicalAnnotation, LabelAnnotation, Literature, MultilinkAnnotation	associated	PD	22626609, 24096968, 25836019
PA165958354	telaprevir	Chemical	ClinicalAnnotation, LabelAnnotation, Literature, MultilinkAnnotation	associated	PD	20648473, 21246582, 23321318, 24096968, 24117654, 24362944
PA166122590	simeprevir	Chemical	ClinicalAnnotation, LabelAnnotation	associated	PD	24602923, 24907224, 28072888
PA166122593	sofosbuvir	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation	associated	PD	25734178, 27357737, 28100007, 29107709, 29534310, 30431653
PA166128130	deleobuvir	Chemical	ClinicalAnnotation	associated	PD	23944300
PA166128132	faldaprevir	Chemical	ClinicalAnnotation	associated	PD	23944300
PA166128166	ledipasvir	Chemical	ClinicalAnnotation	associated	PD	25734178, 27357737, 28100007
PA166128167	daclatasvir	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation	associated	PD	25080450, 30431653
PA166131629	sustained virological response (svr)	Disease	VariantAnnotation	associated	PD	30431653
PA166155435	rs8099917	Variant	LabelAnnotation	associated
PA166155437	rs8103142	Variant	LabelAnnotation	associated
PA166155468	rs12979860	Variant	LabelAnnotation	associated
PA166160002	dasabuvir / ombitasvir / paritaprevir / ritonavir	Chemical	LabelAnnotation	associated
PA166163408	ombitasvir / paritaprevir / ritonavir	Chemical	LabelAnnotation	associated
PA166163411	dasabuvir	Chemical	LabelAnnotation	associated
PA166163415	velpatasvir	Chemical	ClinicalAnnotation	associated	PD	29107709
PA166163416	sofosbuvir / velpatasvir	Chemical	LabelAnnotation	associated
PA166163427	ledipasvir / sofosbuvir	Chemical	LabelAnnotation	associated
PA166163438	elbasvir / grazoprevir	Chemical	LabelAnnotation	associated
PA166171182	voxilaprevir	Chemical	ClinicalAnnotation	associated	PD	29107709
PA166177517	sofosbuvir / velpatasvir / voxilaprevir	Chemical	LabelAnnotation	associated
PA444445	Hepatitis C	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	19684573, 19749757, 20399780, 20578254, 20621700, 20728570, 20804372, 20964522, 21068134, 21112657, 21145807, 21374656, 21447862, 21466653, 21537116, 21572301, 21606533, 21726252, 21907615, 21911885, 21951981, 21993426, 22328925, 22345656, 22438096, 22863269, 23142377, 23281610, 23321318, 23383658, 23490377, 24072198, 24102823, 24117654, 24308755, 24768758, 25287681, 25918016, 25958342, 26032235, 26186989, 26284539, 26902034, 27498543, 27514956, 27714501, 27833958, 28261910, 28703131, 28739427, 30450628
PA445016	Myeloproliferative Disorders	Disease	ClinicalAnnotation	associated	PD	29369421
PA445506	Recurrence	Disease	ClinicalAnnotation	associated	PD	28100007
PA446862	Hepatitis B, Chronic	Disease	ClinicalAnnotation	associated	PD	28453395, 30016335, 31201901
PA446863	Hepatitis C, Chronic	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	19749757, 19749758, 20060832, 20434452, 20648473, 21068134, 21112657, 21112660, 21145807, 21246582, 21254157, 21346780, 21360545, 21374656, 21384511, 21390311, 21466653, 21503910, 21739446, 21745312, 21907615, 21911885, 21987611, 22301466, 22328925, 22345656, 22438096, 22626609, 22863269, 23142377, 23281610, 23321318, 23730840, 23944300, 24102823, 24117654, 24308755, 24355007, 24362944, 24602923, 24768758, 24907224, 24929144, 25080450, 25534433, 25734178, 25769643, 26003758, 26825765, 27357737, 28072888, 28100007, 29107709, 29534310, 30431653
PA447230	HIV	Disease	ClinicalAnnotation	associated	PD	19749757, 22328925, 23281610, 25287681, 26186989
PA451241	ribavirin	Chemical	ClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	associated	PD	19684573, 19749757, 19749758, 20060832, 20399780, 20434452, 20578254, 20621700, 20648473, 20728570, 20804372, 20964522, 21068134, 21112657, 21112660, 21145807, 21246582, 21254157, 21346780, 21360545, 21374656, 21384511, 21390311, 21447862, 21466653, 21503910, 21537116, 21572301, 21606533, 21726252, 21739446, 21745312, 21907615, 21911885, 21951981, 21987611, 21993426, 22301466, 22328925, 22345656, 22438096, 22626609, 22863269, 23142377, 23281610, 23321318, 23383658, 23490377, 23730840, 24072198, 24096968, 24102823, 24117654, 24308755, 24355007, 24362944, 24602923, 24768758, 24907224, 24929144, 25080450, 25287681, 25534433, 25769643, 25918016, 25958342, 26003758, 26032235, 26186989, 26284539, 26825765, 26902034, 27498543, 27514956, 27714501, 27833958, 28072888, 28261910, 28703131, 28739427, 30450628
PA451999	interferons	Chemical	ClinicalAnnotation	associated	PD	19749757, 19749758, 20060832, 20434452, 21068134, 21112657, 21112660, 21145807, 21254157, 21360545, 21374656, 21384511, 21466653, 21503910, 21739446, 21745312, 21907615, 21911885, 22301466, 22345656, 22438096, 22863269, 23142377, 23281610, 23730840, 24102823, 24308755, 24355007, 24768758, 24929144, 26003758, 26825765

References

Pubmed ID	Year	Title	Citations
38193711	2024	IFN-λ3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans.	0
38193711	2024	IFN-λ3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans.	0
36655749	2023	IFNL3/4 polymorphisms as a two-edged sword: An association with COVID-19 outcome.	2
36682084	2023	IFN-λ3 and CCL17 as predictors of disease progression in patients with mild to moderate COVID-19: A cohort study in a real-world setting.	1
36708570	2023	The Impact of interferon lambda 3 Polymorphism on Hepato-Cellular Carcinoma Progression in Hepatitis C Virus Patients: Treatment-Naïve and Experienced.	0
37812032	2023	Its all about IFN-λ4: Protective role of IFNL4 polymorphism against COVID-19-related pneumonia in females.	1
38406928	2023	Predictive Potential Of Il28b Gene In Hcv Patients, Resistant To Daclatasvir And Sofosbuvir In KPK Population.	0
36655749	2023	IFNL3/4 polymorphisms as a two-edged sword: An association with COVID-19 outcome.	2
36682084	2023	IFN-λ3 and CCL17 as predictors of disease progression in patients with mild to moderate COVID-19: A cohort study in a real-world setting.	1
36708570	2023	The Impact of interferon lambda 3 Polymorphism on Hepato-Cellular Carcinoma Progression in Hepatitis C Virus Patients: Treatment-Naïve and Experienced.	0
37812032	2023	Its all about IFN-λ4: Protective role of IFNL4 polymorphism against COVID-19-related pneumonia in females.	1
38406928	2023	Predictive Potential Of Il28b Gene In Hcv Patients, Resistant To Daclatasvir And Sofosbuvir In KPK Population.	0
31793339	2022	PNPLA3 and IL 28B signature for predicting susceptibility to chronic hepatitis C infection and fibrosis progression.	10
34047252	2022	IL28B, TLR7 SNPs, and cytomegalovirus infection are risk factors for advanced liver disease in chronic hepatitis C patients.	1
34817649	2022	Possible relationship between IL28B rs12979860 and TLR2 -196 to -174 del/ins polymorphisms and the liver fibrosis stage in hepatitis C patients.	1

Citation

Dessen P

IFNL3 (interferon lambda 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51058/ifnl3

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