IFNL3 (interferon lambda 3)

2009-09-01 Affiliation

Identity

HGNC

IFNL3

LOCATION

19q13.2

LOCUSID

282617

ALIAS

IFN-lambda-3,IFN-lambda-4,IL-28B,IL-28C,IL28B,IL28C

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 282617
MIM: 607402
HGNC: 18365
Ensembl: ENSG00000197110

Variants:

dbSNP: 282617
ClinVar: 282617
TCGA: ENSG00000197110
COSMIC: IFNL3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000197110	ENST00000413851	Q8IZI9
ENSG00000197110	ENST00000613087	A0A0C4DGW8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Jak-STAT signaling pathway	KEGG	ko04630
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Jak-STAT signaling pathway	KEGG	hsa04630
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164749390	peginterferon alfa-2a	Chemical	ClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	associated	PD	19684573, 19749757, 19749758, 20060832, 20399780, 20434452, 20578254, 20621700, 20648473, 20728570, 20804372, 20964522, 21068134, 21112657, 21112660, 21145807, 21246582, 21254157, 21346780, 21360545, 21374656, 21384511, 21390311, 21447862, 21466653, 21503910, 21537116, 21572301, 21606533, 21726252, 21739446, 21745312, 21907615, 21911885, 21951981, 21987611, 21993426, 22301466, 22328925, 22345656, 22438096, 22863269, 23142377, 23281610, 23321318, 23383658, 23490377, 23730840, 24072198, 24096968, 24102823, 24117654, 24308755, 24355007, 24362944, 24602923, 24768758, 24907224, 24929144, 25080450, 25287681, 25534433, 25769643, 25918016, 25958342, 26003758, 26032235, 26186989, 26284539, 26825765, 26902034, 27498543, 27514956, 27714501, 27833958, 28072888, 28261910, 28453395, 28703131, 28739427, 29369421, 30016335, 30450628, 31201901
PA164784024	peginterferon alfa-2b	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	associated	PD	19684573, 19749757, 19749758, 20060832, 20399780, 20434452, 20578254, 20621700, 20648473, 20728570, 20804372, 20964522, 21068134, 21112657, 21112660, 21145807, 21246582, 21254157, 21346780, 21360545, 21374656, 21384511, 21390311, 21447862, 21466653, 21503910, 21537116, 21572301, 21606533, 21726252, 21739446, 21745312, 21907615, 21911885, 21951981, 21987611, 21993426, 22301466, 22328925, 22345656, 22438096, 22626609, 22863269, 23142377, 23281610, 23321318, 23383658, 23490377, 23730840, 24072198, 24096968, 24102823, 24117654, 24308755, 24355007, 24362944, 24602923, 24768758, 24907224, 24929144, 25080450, 25287681, 25534433, 25769643, 25918016, 25958342, 26003758, 26032235, 26186989, 26284539, 26825765, 26902034, 27498543, 27514956, 27714501, 27833958, 28072888, 28261910, 28703131, 28739427, 29369421, 30450628
PA165948902	boceprevir	Chemical	ClinicalAnnotation, LabelAnnotation, Literature, MultilinkAnnotation	associated	PD	22626609, 24096968, 25836019
PA165958354	telaprevir	Chemical	ClinicalAnnotation, LabelAnnotation, Literature, MultilinkAnnotation	associated	PD	20648473, 21246582, 23321318, 24096968, 24117654, 24362944
PA166122590	simeprevir	Chemical	ClinicalAnnotation, LabelAnnotation	associated	PD	24602923, 24907224, 28072888
PA166122593	sofosbuvir	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation	associated	PD	25734178, 27357737, 28100007, 29107709, 29534310, 30431653
PA166128130	deleobuvir	Chemical	ClinicalAnnotation	associated	PD	23944300
PA166128132	faldaprevir	Chemical	ClinicalAnnotation	associated	PD	23944300
PA166128166	ledipasvir	Chemical	ClinicalAnnotation	associated	PD	25734178, 27357737, 28100007
PA166128167	daclatasvir	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation	associated	PD	25080450, 30431653
PA166131629	sustained virological response (svr)	Disease	VariantAnnotation	associated	PD	30431653
PA166155435	rs8099917	Variant	LabelAnnotation	associated
PA166155437	rs8103142	Variant	LabelAnnotation	associated
PA166155468	rs12979860	Variant	LabelAnnotation	associated
PA166160002	dasabuvir / ombitasvir / paritaprevir / ritonavir	Chemical	LabelAnnotation	associated
PA166163408	ombitasvir / paritaprevir / ritonavir	Chemical	LabelAnnotation	associated
PA166163411	dasabuvir	Chemical	LabelAnnotation	associated
PA166163415	velpatasvir	Chemical	ClinicalAnnotation	associated	PD	29107709
PA166163416	sofosbuvir / velpatasvir	Chemical	LabelAnnotation	associated
PA166163427	ledipasvir / sofosbuvir	Chemical	LabelAnnotation	associated
PA166163438	elbasvir / grazoprevir	Chemical	LabelAnnotation	associated
PA166171182	voxilaprevir	Chemical	ClinicalAnnotation	associated	PD	29107709
PA166177517	sofosbuvir / velpatasvir / voxilaprevir	Chemical	LabelAnnotation	associated
PA444445	Hepatitis C	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	19684573, 19749757, 20399780, 20578254, 20621700, 20728570, 20804372, 20964522, 21068134, 21112657, 21145807, 21374656, 21447862, 21466653, 21537116, 21572301, 21606533, 21726252, 21907615, 21911885, 21951981, 21993426, 22328925, 22345656, 22438096, 22863269, 23142377, 23281610, 23321318, 23383658, 23490377, 24072198, 24102823, 24117654, 24308755, 24768758, 25287681, 25918016, 25958342, 26032235, 26186989, 26284539, 26902034, 27498543, 27514956, 27714501, 27833958, 28261910, 28703131, 28739427, 30450628
PA445016	Myeloproliferative Disorders	Disease	ClinicalAnnotation	associated	PD	29369421
PA445506	Recurrence	Disease	ClinicalAnnotation	associated	PD	28100007
PA446862	Hepatitis B, Chronic	Disease	ClinicalAnnotation	associated	PD	28453395, 30016335, 31201901
PA446863	Hepatitis C, Chronic	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	19749757, 19749758, 20060832, 20434452, 20648473, 21068134, 21112657, 21112660, 21145807, 21246582, 21254157, 21346780, 21360545, 21374656, 21384511, 21390311, 21466653, 21503910, 21739446, 21745312, 21907615, 21911885, 21987611, 22301466, 22328925, 22345656, 22438096, 22626609, 22863269, 23142377, 23281610, 23321318, 23730840, 23944300, 24102823, 24117654, 24308755, 24355007, 24362944, 24602923, 24768758, 24907224, 24929144, 25080450, 25534433, 25734178, 25769643, 26003758, 26825765, 27357737, 28072888, 28100007, 29107709, 29534310, 30431653
PA447230	HIV	Disease	ClinicalAnnotation	associated	PD	19749757, 22328925, 23281610, 25287681, 26186989
PA451241	ribavirin	Chemical	ClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	associated	PD	19684573, 19749757, 19749758, 20060832, 20399780, 20434452, 20578254, 20621700, 20648473, 20728570, 20804372, 20964522, 21068134, 21112657, 21112660, 21145807, 21246582, 21254157, 21346780, 21360545, 21374656, 21384511, 21390311, 21447862, 21466653, 21503910, 21537116, 21572301, 21606533, 21726252, 21739446, 21745312, 21907615, 21911885, 21951981, 21987611, 21993426, 22301466, 22328925, 22345656, 22438096, 22626609, 22863269, 23142377, 23281610, 23321318, 23383658, 23490377, 23730840, 24072198, 24096968, 24102823, 24117654, 24308755, 24355007, 24362944, 24602923, 24768758, 24907224, 24929144, 25080450, 25287681, 25534433, 25769643, 25918016, 25958342, 26003758, 26032235, 26186989, 26284539, 26825765, 26902034, 27498543, 27514956, 27714501, 27833958, 28072888, 28261910, 28703131, 28739427, 30450628
PA451999	interferons	Chemical	ClinicalAnnotation	associated	PD	19749757, 19749758, 20060832, 20434452, 21068134, 21112657, 21112660, 21145807, 21254157, 21360545, 21374656, 21384511, 21466653, 21503910, 21739446, 21745312, 21907615, 21911885, 22301466, 22345656, 22438096, 22863269, 23142377, 23281610, 23730840, 24102823, 24308755, 24355007, 24768758, 24929144, 26003758, 26825765

References

Pubmed ID	Year	Title	Citations
12483210	2003	IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.	581
12469119	2003	IL-28, IL-29 and their class II cytokine receptor IL-28R.	481
23420232	2013	Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts.	77
21402922	2011	Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection.	55
21390311	2011	Response prediction in chronic hepatitis C by assessment of IP-10 and IL28B-related single nucleotide polymorphisms.	52
21931540	2011	IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study.	47
21254158	2011	Quantitation of pretreatment serum interferon-γ-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response.	42
23950709	2013	A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication.	40
22192885	2012	Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection.	37
22314430	2012	IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease.	33

Citation

Dessen P

IFNL3 (interferon lambda 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51058/ifnl3