IFNL4 (interferon lambda 4 (gene/pseudogene))

2016-10-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
IFNAN

Other Information

Locus ID:

NCBI: 101180976
MIM: 615090
HGNC: 44480
Ensembl: ENSG00000272395

Variants:

dbSNP: 101180976
ClinVar: 101180976
TCGA: ENSG00000272395
COSMIC: IFNL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000272395ENST00000616270K9M1A9

Expression (GTEx)

0
1

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164749390peginterferon alfa-2aChemicalClinicalAnnotationassociatedPD19684573, 20399780, 20578254, 20621700, 20648473, 20728570, 20804372, 20964522, 21068134, 21112657, 21145807, 21246582, 21374656, 21447862, 21466653, 21537116, 21572301, 21606533, 21726252, 21907615, 21911885, 21951981, 21993426, 22345656, 22438096, 22863269, 23142377, 23321318, 23383658, 23490377, 24072198, 24102823, 24117654, 24308755, 24602923, 24768758, 24907224, 25080450, 25534433, 25918016, 25958342, 26032235, 26284539, 26902034, 27027531, 27498543, 27514956, 27714501, 27833958, 28072888, 28261910, 28453395, 28703131, 28739427, 29369421, 30016335, 30450628, 31201901
PA164784024peginterferon alfa-2bChemicalClinicalAnnotationassociatedPD19684573, 20399780, 20578254, 20621700, 20648473, 20728570, 20804372, 20964522, 21068134, 21112657, 21145807, 21246582, 21374656, 21447862, 21466653, 21537116, 21572301, 21606533, 21726252, 21907615, 21911885, 21951981, 21993426, 22345656, 22438096, 22626609, 22863269, 23142377, 23321318, 23383658, 23490377, 24072198, 24102823, 24117654, 24308755, 24602923, 24768758, 24907224, 25080450, 25534433, 25918016, 25958342, 26032235, 26284539, 26902034, 27027531, 27498543, 27514956, 27714501, 27833958, 28072888, 28261910, 28703131, 28739427, 29369421, 30450628
PA165948902boceprevirChemicalClinicalAnnotationassociatedPD22626609
PA165958354telaprevirChemicalClinicalAnnotationassociatedPD20648473, 21246582, 23321318, 24117654
PA166122590simeprevirChemicalClinicalAnnotationassociatedPD24602923, 24907224, 27027531, 28072888
PA166122593sofosbuvirChemicalClinicalAnnotation, LabelAnnotation, VariantAnnotationassociatedPD25734178, 27357737, 28100007, 29107709, 29534310, 29866411, 30431653, 31260374
PA166128130deleobuvirChemicalClinicalAnnotationassociatedPD23944300
PA166128132faldaprevirChemicalClinicalAnnotationassociatedPD23944300
PA166128166ledipasvirChemicalClinicalAnnotationassociatedPD25734178, 27357737, 28100007
PA166128167daclatasvirChemicalClinicalAnnotation, VariantAnnotationassociatedPD25080450, 30431653
PA166131629sustained virological response (svr)DiseaseVariantAnnotationassociatedPD30431653
PA166155468rs12979860VariantLabelAnnotationassociated
PA166163408ombitasvir / paritaprevir / ritonavirChemicalLabelAnnotationassociated
PA166163415velpatasvirChemicalClinicalAnnotationassociatedPD29107709
PA166171182voxilaprevirChemicalClinicalAnnotationassociatedPD29107709
PA166179660direct acting antiviralsChemicalClinicalAnnotationassociatedPD29866411, 31260374
PA444445Hepatitis CDiseaseClinicalAnnotationassociatedPD19684573, 20399780, 20578254, 20621700, 20728570, 20804372, 20964522, 21068134, 21112657, 21145807, 21374656, 21447862, 21466653, 21537116, 21572301, 21606533, 21726252, 21907615, 21911885, 21951981, 21993426, 22345656, 22438096, 22863269, 23142377, 23321318, 23383658, 23490377, 24072198, 24102823, 24117654, 24308755, 24768758, 25918016, 25958342, 26032235, 26284539, 26902034, 27498543, 27514956, 27714501, 27833958, 28261910, 28703131, 28739427, 30450628
PA445016Myeloproliferative DisordersDiseaseClinicalAnnotationassociatedPD29369421
PA445506RecurrenceDiseaseClinicalAnnotationassociatedPD28100007
PA446862Hepatitis B, ChronicDiseaseClinicalAnnotationassociatedPD28453395, 30016335, 31201901
PA446863Hepatitis C, ChronicDiseaseClinicalAnnotation, VariantAnnotationassociatedPD20648473, 21246582, 22626609, 23321318, 23944300, 24117654, 24602923, 24907224, 25080450, 25534433, 25734178, 27027531, 27357737, 28072888, 28100007, 29107709, 29534310, 29866411, 30431653, 31260374
PA451241ribavirinChemicalClinicalAnnotationassociatedPD19684573, 20399780, 20578254, 20621700, 20648473, 20728570, 20804372, 20964522, 21068134, 21112657, 21145807, 21246582, 21374656, 21447862, 21466653, 21537116, 21572301, 21606533, 21726252, 21907615, 21911885, 21951981, 21993426, 22345656, 22438096, 22626609, 22863269, 23142377, 23321318, 23383658, 23490377, 24072198, 24102823, 24117654, 24308755, 24602923, 24768758, 24907224, 25080450, 25534433, 25918016, 25958342, 26032235, 26284539, 26902034, 27027531, 27498543, 27514956, 27714501, 27833958, 28072888, 28261910, 28703131, 28739427, 30450628
PA451999interferonsChemicalClinicalAnnotationassociatedPD22438096

References

Pubmed IDYearTitleCitations
279866892017HLA-B*57 and IFNL4-related polymorphisms are associated with protection against HIV-1 disease progression in controllers.13
286305012017IFN-λ4 potently blocks IFN-α signalling by ISG15 and USP18 in hepatitis C virus infection.10
256751032015IFNL4 and IFNL3 associated polymorphisms strongly influence the spontaneous IFN-alpha receptor-1 expression in HCV-infected patients.2
272361522016 Association of HLA-DQ and IFNL4 polymorphisms with susceptibility to hepatitis B virus infection and clearance.2
290802692018Role of Functional IFNL4, IFNLR1, IFNA, IFNAR2 Polymorphisms in Hepatitis B virus-related liver disease in Han Chinese population.2
302477852018IFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex.1
232915882013A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.0
239564382014Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus.0
242058312014Polymorphisms of interferon-λ4 and IL28B - effects on treatment response to interferon/ribavirin in patients with chronic hepatitis C.0
243254052014Role of IL28B for chronic hepatitis C treatment toward personalized medicine.0

Citation

Dessen P

IFNL4 (interferon lambda 4 (gene/pseudogene))

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56497/ifnl4