IGHE (immunoglobulin heavy constant epsilon)

2011-02-01 Affiliation

Identity

HGNC

IGHE

LOCATION

14q32.33

LOCUSID

3497

ALIAS

IgE

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3497
MIM: 147180
HGNC: 5522
Ensembl: ENSG00000211891
IMGT/GENE-DB:

Variants:

dbSNP: 3497
ClinVar: 3497
TCGA: ENSG00000211891
COSMIC: IGHE

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000211891	ENST00000390541	P01854
ENSG00000211891	ENST00000641420	A0A286YES5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
FCERI mediated Ca+2 mobilization	REACTOME	R-HSA-2871809
FCERI mediated NF-kB activation	REACTOME	R-HSA-2871837
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807

References

Pubmed ID	Year	Title	Citations
21516097	2011	Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.	48
15814733	2005	Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis.	46
18356810	2008	Basophil phenotypes in chronic idiopathic urticaria in relation to disease activity and autoantibodies.	32
20808937	2010	Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population.	27
19682998	2009	Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms.	20
15356573	2004	Synthesis of IL-13 by human B lymphocytes: regulation and role in IgE production.	16
21526166	2011	IgE mediates killing of intracellular Toxoplasma gondii by human macrophages through CD23-dependent, interleukin-10 sensitive pathway.	16
21050946	2010	Does genetic regulation of IgE begin in utero? Evidence from T(H)1/T(H)2 gene polymorphisms and cord blood total IgE.	15
22194960	2011	Immunoglobulin E and mast cell proteases are potential risk factors of human pre-diabetes and diabetes mellitus.	15
21051082	2010	Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program.	13

Citation

Dessen P

IGHE (immunoglobulin heavy constant epsilon)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52095/ighe