IGKC (immunoglobulin kappa constant)

2012-09-01  

Identity

HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
HCAK1,IGKCD,Km
FUSION GENES

Other Information

Locus ID:

NCBI: 3514
MIM: 147200
HGNC: 5716
Ensembl: ENSG00000211592
IMGT/GENE-DB:

Variants:

dbSNP: 3514
ClinVar: 3514
TCGA: ENSG00000211592
COSMIC: IGKC

RNA/Proteins

Expression (GTEx)

0
5000
10000
15000
20000
25000
30000

References

Pubmed IDYearTitleCitations
223516852012A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin κ C as a compatible prognostic marker in human solid tumors.72
233702242013The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer.39
233036722013High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region.28
217015352011The morphologic spectrum and clinical significance of light chain proximal tubulopathy with and without crystal formation.19
117000592001Both the environment and somatic mutations govern the aggregation pathway of pathogenic immunoglobulin light chain.18
208707232010Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils.18
188216752008Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies.13
230286002012Immunoglobulin kappa C predicts overall survival in node-negative breast cancer.9
120395242002TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis.6
120395242002TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis.6

Citation

Dessen P

IGKC (immunoglobulin kappa constant)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52874/igkc