IGLC1 (immunoglobulin lambda constant 1)

2014-11-01 Affiliation

Identity

HGNC

IGLC1

LOCATION

22q11.22

LOCUSID

3537

ALIAS

IGLC

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3537
MIM: 147220
HGNC: 5855
Ensembl: ENSG00000211675
IMGT/GENE-DB:

Variants:

dbSNP: 3537
ClinVar: 3537
TCGA: ENSG00000211675
COSMIC: IGLC1

RNA/Proteins

Expression (GTEx)

500

1000

1500

2000

2500

3000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	REACTOME	R-HSA-983695
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933
Innate Immune System	REACTOME	R-HSA-168249
Complement cascade	REACTOME	R-HSA-166658
Initial triggering of complement	REACTOME	R-HSA-166663
Creation of C4 and C2 activators	REACTOME	R-HSA-166786
Classical antibody-mediated complement activation	REACTOME	R-HSA-173623
Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME	R-HSA-2029480
FCGR activation	REACTOME	R-HSA-2029481
Regulation of actin dynamics for phagocytic cup formation	REACTOME	R-HSA-2029482
Role of phospholipids in phagocytosis	REACTOME	R-HSA-2029485
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
FCERI mediated Ca+2 mobilization	REACTOME	R-HSA-2871809
FCERI mediated NF-kB activation	REACTOME	R-HSA-2871837
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Binding and Uptake of Ligands by Scavenger Receptors	REACTOME	R-HSA-2173782
Scavenging of heme from plasma	REACTOME	R-HSA-2168880
CD22 mediated BCR regulation	REACTOME	R-HSA-5690714

References

Pubmed ID	Year	Title	Citations
23303672	2013	High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region.	28
12077254	2002	Unraveling of the polymorphic C lambda 2-C lambda 3 amplification and the Ke+Oz- polymorphism in the human Ig lambda locus.	4

Citation

Dessen P

IGLC1 (immunoglobulin lambda constant 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64565/iglc1