IHH (Indian hedgehog signaling molecule)

2007-02-01  

Identity

HGNC
LOCATION
2q35
LOCUSID
ALIAS
BDA1,HHG2

Other Information

Locus ID:

NCBI: 3549
MIM: 600726
HGNC: 5956
Ensembl: ENSG00000163501

Variants:

dbSNP: 3549
ClinVar: 3549
TCGA: ENSG00000163501
COSMIC: IHH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163501ENST00000295731Q14623

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Hedgehog signaling pathwayKEGGko04340
Hedgehog signaling pathwayKEGGhsa04340
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Hedgehog signalingKEGGhsa_M00678
Hedgehog signalingKEGGM00678
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Hh mutants abrogate ligand secretionREACTOMER-HSA-5387390
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog ligand biogenesisREACTOMER-HSA-5358346
Release of Hh-Np from the secreting cellREACTOMER-HSA-5362798
Hedgehog 'on' stateREACTOMER-HSA-5632684
Ligand-receptor interactionsREACTOMER-HSA-5632681
Activation of SMOREACTOMER-HSA-5635838
HHAT G278V abrogates palmitoylation of Hh-NpREACTOMER-HSA-5658034

References

Pubmed IDYearTitleCitations
372569342023Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis.8
372569342023Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis.8
340705462021Highly Conserved C-Terminal Region of Indian Hedgehog N-Fragment Contributes to Its Auto-Processing and Multimer Formation.0
345301442021Acrocapitofemoral dysplasia: Novel mutation in IHH in two adult patients from the third family in the literature and progression of the disease.0
340705462021Highly Conserved C-Terminal Region of Indian Hedgehog N-Fragment Contributes to Its Auto-Processing and Multimer Formation.0
345301442021Acrocapitofemoral dysplasia: Novel mutation in IHH in two adult patients from the third family in the literature and progression of the disease.0
318200362020HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.16
322090482020A novel variant of IHH in a Chinese family with brachydactyly type 1.4
322350062020Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway.21
323110392020Clinical and Molecular Description of 16 Families With Heterozygous IHH Variants.5
318200362020HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.16
322090482020A novel variant of IHH in a Chinese family with brachydactyly type 1.4
322350062020Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway.21
323110392020Clinical and Molecular Description of 16 Families With Heterozygous IHH Variants.5
306510742019p.E95K mutation in Indian hedgehog causing brachydactyly type A1 impairs IHH/Gli1 downstream transcriptional regulation.4

Citation

Dessen P

IHH (Indian hedgehog signaling molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43961/ihh