IHH (Indian hedgehog signaling molecule)

2007-02-01  

Identity

HGNC
IHH
LOCATION
2q35
LOCUSID
3549
ALIAS
BDA1,HHG2

Other Information

Locus ID:

NCBI: 3549
MIM: 600726
HGNC: 5956
Ensembl: ENSG00000163501

Variants:

dbSNP: 3549
ClinVar: 3549
TCGA: ENSG00000163501
COSMIC: IHH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163501ENST00000295731Q14623

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hedgehog signaling pathwayKEGGko04340
Hedgehog signaling pathwayKEGGhsa04340
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Hedgehog signalingKEGGhsa_M00678
Hedgehog signalingKEGGM00678
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Hh mutants abrogate ligand secretionREACTOMER-HSA-5387390
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog ligand biogenesisREACTOMER-HSA-5358346
Release of Hh-Np from the secreting cellREACTOMER-HSA-5362798
Hedgehog 'on' stateREACTOMER-HSA-5632684
Ligand-receptor interactionsREACTOMER-HSA-5632681
Activation of SMOREACTOMER-HSA-5635838
HHAT G278V abrogates palmitoylation of Hh-NpREACTOMER-HSA-5658034

References

Pubmed IDYearTitleCitations
145204112003Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.370
183919522008Genome-wide association analysis identifies 20 loci that influence adult height.322
173604752007Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.162
147701822004Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation.112
216423792011The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification.109
114765782001The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides.81
188295342008Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells.80
163220882006Hedgehog signaling maintains resident hepatic progenitors throughout life.79
194459422009Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.66
235754782013Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors.56

Citation

Dessen P

IHH (Indian hedgehog signaling molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43961/ihh